FAKTOR RISIKO TRANSMISI INTRAFAMILIAL PENDERITA HBsAg POSITIF DI KOTA MATARAM NUSA TENGGARA BARAT

• Main Authors: , Bai Kusnadi, , Prof. dr. Siti Nurdjanah, M. Kes, SpPD, KGEH.
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2011
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/91110/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=53055
• Institution: Universitas Gadjah Mada

Background: Hepatitis B is a disease with high prevalence, it may cause problems in post-acute, chronic, cyrrhosis , primary hepatocellular carcinoma, morbidity, and mortality. World Health Organization estimates more than 2 billion people are infected by HBV. About 400 million people worldwide suffer from chronic HBV infection, with 500,000 of them dying. Prevalence among countries vary between 0.1% -20%. In Indonesia, the prevalence of HBsAg ranged from 3-17%. In West Nusa Tenggara (NTB), hepatitis B carrier rate ranged between 3.9%-20.3% (1982-1990) and 1.4% -12.5% (2002-2007). In the city of Mataram the prevalence of HBsAg is around 10%. Transmission of hepatitis B occur contact family (intrafamilial transmission), then conducted research to knowing the risk factors intrafamilial transmission of patients with HBsAg (+). So it can be done prevention HBsAg (+) in the family. Methods: A case-control study of the risk factor of family members of patiensts HBsAg (+). Risk factor are a history of unsafe intercourse sex research with people with HBsAg (+), a history of sharing personal equipment (cutlery/drink, razors, toothbrushes, towels) a history of parents with HBsAg (+). Interviewed 124 people of cases and controls (ratio 1:1).Analysid with Chi-square (X 2 ), Odds Ratio, and multiple logistic regression. Results: Bivariate analysis showed a history of unsafe sex (OR=2.000, 95%CI= 0.641-6.651), use of utensils/drinking (OR=1.069, 95CI%=0.489- 2.340), razors (OR=2.230, 95%CI=0.516-11.215), towels (OR = 1.455, 95CI% = 0.486-4.519) the sharing and a history pf parents with HBsAg (+)(OR=2.703, 95%CI=1.227-5.987) was rather a risk factor, and both parents (father and mother) HBsAg(+) (OR=0.254, 95%CI=0.064-0.969) are protective. Multivariate analysis showed unsafe sex (aOR=4.274, 95%CI=1.294-14.117) and a history of parents with mother suffering from HBsAg (+) (OR = 7.743, 95% CI = 2.566-23.363) is a risk factor for patients suffering from HBsAg (+) in the family and both parents (father and mother) HBsAg (+)(OR=0.254, 95%CI=0.064-0.969) are protective. Conclusion: Unsafe sex with HBsAg (+)(aOR=4.274, 95%CI=1.294- 14.117), history of parents with mother suffering from HBsAg (+) (OR = 7.743, 95% CI = 2.566-23.363) was a risk to suffer from HBsAg positive in the family and both parents (father and mother) HBsAg(+) are protective. While the contact use utensils /drinking, sharing the shaver, tools, toothbrushes, towels was not a risk factor for suffering from HBsAg positive in the family.