IMMOBILIZATION OF BOMBYX MORl'S SERICIN ON POL Y(L-LACTIC ACID) FILMS AND ITS EFFECT ON SURFACE HYDROPHILICITY

• Main Author: , Yenny Yustisia
• Format: Article NonPeerReviewed
• Published: [Yogyakarta] : Fak.Kedokteran Gigi Universitas Gadjah Mada 2012
• Online Access: https://repository.ugm.ac.id/96085/; http://repository.ugm.ac.id/digitasi/index.php?module=cari_hasil_full&idbuku=3903
• Institution: Universitas Gadjah Mada

<p>Poly (L-lacticacid) or PLLA as one of tissue engineering material have demonstrated low cell interaction capability due to its hydrophobicity. Bombyx mori's sericin, a natural polymer protein, contains large amount of polar functional group which has hydrophilic characteristic. The aim of this study was to modified PLLAsurface using Bombyx mori's sericin and to investigate its effect on surface hydrophilicity.<br /> Three concentration of sericin (2.5, 5, and 10 mg/ml) were applied on PLLAsurface modification using carbodiimide chemistry. Surface characterization using Fourier Transform-Infrared Spectroscopy (FTIR)was performed to observe the changes on surface-modified PLLA.The evaluation of surface hydrophilicity was made through water contact angle measurements.<br /> FTIR graphs showed that new absorbtion bands located at 1597 cm-1 has appear assigned to the amide bond (N-H) which indicates that sericin was successfully immobilized to PLLAsurface by carbodiimide chemistry. The contact angle ofPLLAsurface was measured to be&plusmn