ACTIVATION OF INNATE IMMUNITY THROUGH TOll-LIKE RECEPTOR-2 BY LlPOTEICHOIC ACID BACTERIA ENTEROCOCCUS FAECALIS

• Main Author: , TamaraYuanita
• Format: Article NonPeerReviewed
• Published: [Yogyakarta] : Fak.Kedokteran Gigi Universitas Gadjah Mada 2012
• Online Access: https://repository.ugm.ac.id/96114/; http://repository.ugm.ac.id/digitasi/index.php?module=cari_hasil_full&idbuku=3932
• Institution: Universitas Gadjah Mada

<p>A persistent infection after root canal preparation is the main etiology in root canal treatment failure. Cleanup the complete of root canal preparation is difficultto achieve because of the complexity of root canal anatomy. The bacteria Enterococcus faecalis (E.faecalis) is the largest species found in root canal treatment failure. Prevalence in the re-treatment amounting to 89.6% and 67.5% for primary infection. Lipoteichoicacid (LTA) is a molecule found in Gram-positive bacterial cell surface that isfunctionally an important factor for growth and survivalof bacteria. TLR-2is a receptor expressed on the cell surface that recognize foreign substances such as bacteria. The conclusion of this paper is the destruction of microbes that cause infections is of paramount importance to prevent re-infection. E.faecalis is a bacteria that is resistant to root canal treatment procedures so that it can be a cause of failure of root canal treatment through the mechanisms of innate immunity activation ofTLR-2 by LTAbacterium E.faecalis.</p>