PERBEDAAN KADAR PLASMA ENDOTELIN-1 PADA WANITA PENGIDAP DIABETES MELLITUS TIPE 2 DENGAN DISLIPIDEMIA DAN TANPA DISLIPIDEMIA (TINJAUAN PUSTAKA DAN LAPORAN PENELITIAN)
Background. Diabetes Mellitus is associated with an increased risk of atherosclerosis, and coronary artery disease is a major cause of death in patients with diabetes. Dyslipidemia is also a major risk factor for coronary artery disease. Endothelial dysfunction may precede the development of atheros...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2012
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/97485/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=54062 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Background. Diabetes Mellitus is associated with an increased risk of
atherosclerosis, and coronary artery disease is a major cause of death in patients
with diabetes. Dyslipidemia is also a major risk factor for coronary artery disease.
Endothelial dysfunction may precede the development of atherosclerosis from this
conditions. Endothelial markers endothelin-1 (ET-1) were assessed in patients
type 2 Diabetes Mellitus women with dyslipidemia and without dyslipidemia
Aim. To evaluate the difference plasma levels of endothelin-1 in type 2 diabetes
mellitus women with dyslipidemia and without dyslipidemia.
Methods. Cross sectional design was conducted on subjects from outpatients type
2 diabetes mellitus women with dyslipidemia and without dyslipidemia at
endocrinology clinic, Dr. Sardjito General Hospital, Yogyakarta. ELISA
sandwich�s methods was used to measure plasma levels of endothelin-1 from
veins blood. Differences between groups were compared by student�s unpaired ttest
and Mann-Whitney test.
Results. Among 60 subjects, there are 30 with dyslipidemia (50%) and 30 without
dyslipidemia (50%). Median age were 55 (44-59) years old. Plasma levels of
endothelin-1 seemed higher in type 2 diabetes mellitus women with dyslipidemia
than without dyslipidemia although they were not statistically significant (18,94 ±
9,72 ng/ml vs. 15,2 ± 7,91 ng/ml, p=0,108).
Conclusion. The plasma levels of endothelin-1 has no significant different
between type 2 diabetes mellitus women with dyslipidemia and without
dyslipidemia. |
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