PENGARUH PREDNISON TERHADAP TERJADINYA LEKOSITOSIS PADA PASIEN SINDROM NEFROTIK PRIMER

• Main Authors: , TIUR FEBRINA, , dr. Pungky Ardani Kusuma, Sp.A(K)
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2012
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/98439/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=54749
• Institution: Universitas Gadjah Mada

Background: One of the side effects of long- term steroid is the occurrence of leukocytosis that could occur due to the work of drug prednisone themselves. There are differences in imune respons of sensitive steroid and resistant steroid, including celluler imune responses (leukocyte). Different number of glucocorticoid receptor and cytokine in sensitive and resistant steroid affect distributions of leukocyte. Objective: To know the difference leukocytosis occurrence in patients with sensitive and resistant nephrotic syndrome due to prednison treatment. Method: retrospective cohort study using medical records of patients diagnosed with primary nephrotic syndrome from January 2005 until Agust 2011 had 60 mg/m2/day prednisone therapy for 2 weeks. Then see the difference in the occurance leukocytosis sensitive group with steroid resistant uses the chi-square. Result. There are 135 patients with nephrotic syndrome, which concist of 75(55,6%) sensitive nephrotic syndrome and 60 resistant nephrotic syndrome. From 135 primary nephrotic syndrome, 83 patients (61%) experienced leukocytosis. The incidence of steroid sensitive is 44 patients (58%) and resistant steroid 39 patients (65%). With a chi-square analysis, there was no significant differeces in the occurance leukocytosis (p=0,45) in both groups with OR 0,90(95%KI 0,69 � 1,17). Mean differences between 2 groups after 4 weeks full dose was no difference (p=0,81). Conclusion: There is no difference in the occurrence leukocytosis in steroid sensitive and resistant steroid. In nephrotic syndrome patients with leukocytosis should be considered induced by prednison, then use of antibiotic more selectively.