TUMBUH KEMBANG ANAK HIPOTIROID KONGENITAL YANG SUDAH DITERAPI DENGAN LEVO-TIROKSIN SEJAK DINI
Congenital hypothyroid (CH) is one of the preventable etiology of intellectual disability. This prevention managed by early detection and prompt hormone replacement therapy using levothyroxine (L-T4). Unfortunately, early detection for intellectual disability using CH screening is not a government r...
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Main Authors: | , |
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Format: | Theses and Dissertations NonPeerReviewed |
Published: |
[Yogyakarta] : Universitas Gadjah Mada
2012
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Subjects: | |
Online Access: | https://repository.ugm.ac.id/98677/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=55623 |
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Institution: | Universitas Gadjah Mada |
Summary: | Congenital hypothyroid (CH) is one of the preventable etiology of
intellectual disability. This prevention managed by early detection and prompt
hormone replacement therapy using levothyroxine (L-T4). Unfortunately, early
detection for intellectual disability using CH screening is not a government
routine program. This will lead to unprompted treatment of CH cases.The aim of
this study was collecting growth and development features of children with CH
that treated with L-T4.
Design of this study was a case study. Toddler with CH that treated with
L-T4 in Endocrinology Subdivision of Pediatric Clinic of Sanglah Hospital,
Wangaya Hospital and Karangasem Hospital that recorded as outpatients since
2006, were deeply analyzed through their therapy and progression of the disease.
Assessments of development were using mental and motor scale from Bayley II,
while assessments of growth were using anthropometric measurement according
to WHO 2005, and bone maturity was assessed with bone age. Each case was
compared, by their similarities and differences and their impact on growth and
development of the children.
There were 8 cases were analyzed, it consists of 4 men and 8 women, age
of diagnosis is between 3 to 18 months. Five subjects with severe CH 4 subjects
with moderate CH, and 3 CH with clinically Down syndrome. When the diagnosis
is upheld, the mean initial TSH is 130.73 uIU/ml (SD 194.89) and initial FT4
average 0.53 ng/dl (SD 0.53), and the mean of birth weight 2862,50 grams (SD
487,16). Who get early therapy there are 5 cases and 7 cases with nor early
therapy.
Psychomotor developmental index were better on children that given high
starting dose compared to children that given standard dose. Outcome of growth
showed better results after treatment with LT-4, and acceleration of growth can be
achieved with early treatment. |
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