PENGARUH PEMBERIAN LACTOBACILLUS ACIDOPHILLUS TERHADAP PERBAIKAN KLINIS COMMON COLD PADA ANAK
Children contract an average of approximately six colds each year and irrational antibiotic has been prescribed to 60% of cases that potentially cause antibiotic resistency. Some studies in humans have shown that probiotic were effective in reducing the severity of common cold symptoms. The mechanis...
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| Main Authors: | , |
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| 格式: | Theses and Dissertations NonPeerReviewed |
| 出版: |
[Yogyakarta] : Universitas Gadjah Mada
2012
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| 主題: | |
| 在線閱讀: | https://repository.ugm.ac.id/99052/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=54750 |
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| 總結: | Children contract an average of approximately six colds each year and irrational
antibiotic has been prescribed to 60% of cases that potentially cause antibiotic
resistency. Some studies in humans have shown that probiotic were effective in
reducing the severity of common cold symptoms. The mechanisms of probiotic are
attributed to an increase of the innate and acquired immune response. The aim of our
study was to investigate whether the consumption of Lactobacillus acidophilus R0052
and Lactobacillus rhamnosus R0011 in dosage of 0.1 x 10
9
CFU and 1.9 x 10
9
CFU
per day during 7 days influences the severity of symptoms of the common cold in
children.
This study describes a randomized, double-blind, placebo-controlled clinical
trial. 100 children who developed symptoms of the common cold within 24-48 hours
before enrollment were included in the study. Patients in the probiotic group (n=50)
received probiotic capsules containing 0,1x10
9
of Lactobacillus acidophilus and
1,9x10
9
Lactobacillus rhamnosus everyday for 7 days. Patients in the placebo group
(n=50) received similarly administered capsules that contained Saccharum lactis.
Subjective daily symptom scores for cough symptoms, nasal symptoms, pharyngeal
symptoms and systemic symptoms.were used as main outcome measures.
The daily mean symptom score during an episode were were not significantly
different in the probiotic-treated group than in the control group (p>0,05). There was
also a nonsinigficant relative risk reduction in the number of improvement from severity
symptoms score of common cold in both of groups (unadjusted absolute % reduction 0,
P=1). There was no report of adverse events in the probiotic and plasebo group.
Lactobacillus acidophilus R005 and Lactobacillus rhamnosus R0011 in the form and
dosage studied did not significantly reduced the severity of symptoms of the common
cold. |
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