Evaluasi Struktur dan Aplikasi pada Hewan Coba Graft Hydroxyapatite Berpori dari Limbah Cangkang Telur sebagai Substitusi Tulang (uji komparasi dengan graft hydroxyapatite komersial berpori)

• Main Authors: , Yudha Mathan Sakti, , Dr.Rahadyan Magetsari, Sp.OT.,Ph.D.,FICS
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2012
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/99144/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=55098
• Institution: Universitas Gadjah Mada

Introduction The development of economically affordable hydroxyapatite graft is needed for orthopaedic practice in developing country. Materials and Methods This study comprise of graft manufacturing process using egg shell waste as calcium resource for hydroxyapatite production with consecutive development of interconnecting porous structure using sugar, material and structural evaluation of the graft using X Ray Diffractometer (XRD) and Scanning Electron Microscope (SEM), and followed with animal implantation procedure on critical size defect of Rattus Novergicus femur. Result After thermal heating process up to 900°C and subsequent hydrothermal synthesis procedure, we have managed to form hydroxyapatite crystals that match to JCPDS standard with interconnecting pore diameter of 50 � 500μm based on XRD and SEM examination, consecutively. The following animal implantation also showed no significant difference on radiologic (ISOLS) and histological (Lane and Shandu modified by Heiple et.al) score compare to the commercial graft based on Mann Whitney U test with p = 0,364 and p = 0,338 (p > 0, 05). Conclusion Porous � egg shell waste derived hydroxyapatite graft has the material characteristic as standard with comparable structural porosity and equal outcome on bone healing with regards to the commercial porous hydroxyapatite graft.