EKSPRESI GEN GLIKODELIN DALAM ENDOMETRIUM WANITA DENGAN ENDOMETRIOSIS Di KLINIK INFERTILITAS PERMATA HATI RS. Dr. SARDJITO, YOGYAKARTA
Endometriosis is a benign gynecologic illness which its case number increases each year. Endometriosis usually emerges followed by pelvis cronic, menstruation painful and infertility painful. Glycodelin gene is one of the moleculer markers of endometrial function. Glycodelin gene production experien...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2012
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/99878/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=56188 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Endometriosis is a benign gynecologic illness which its case number increases each
year. Endometriosis usually emerges followed by pelvis cronic, menstruation painful
and infertility painful. Glycodelin gene is one of the moleculer markers of
endometrial function. Glycodelin gene production experiences improvement on the
endometrial secretion phase of normal menstruation cycle and this gene is needed for
embryo implantation process, while for women who has low glycodelin gene
endometriosis expression. In order so, it is necessary to conduct research concerning
glycodelin gene expression on endometriosis women patient who joins ART
programe (Assited Reproduction Technology) at Permata Hati Infertility Clinic, Dr.
Sardjito Hospital, Yogyakarta. The aim of this research is to know glycodelin gene
expression level and relationship between that gene expression level with
endometriosis seriousness of condition degree. The quantity of endometrial tissues
which are the sample of this research are six samples taken from normal women and
six samples from endometriosis women on each stadium (stadium I � IV). These
RNA tissues is isolated by using High Pure RNA Tissue Kit produced by Roche
Applied Science and glycodelin gene mRNA amplification using RT-PCR technique.
cDNA glycodelin gene analyzed with electroforesis and analyzed semiqualitative
using the SCION IMAGE or IMAGEJ. The result of the research shows freqnency of
women with endometriosis at Permata Hati Infertility Clinic, Dr. Sardjito Hospital,
Yogyakarta who express glycodelin gene as much as 37,5 % and these is no
relationship between the glycodelin gene expression level with endometriosis
seriousness of condition degree. |
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