Anti-inflammatory activity of roots of Achyranthes aspera

• Main Authors: S., Vijaya Kumar, P., Sankar, R., Varatharajan
• Format: Article
• Language: English
• Published: Taylor & Francis 2009
• Subjects: QR Microbiology
• Online Access: http://eprints.intimal.edu.my/200/1/1.pdf; http://eprints.intimal.edu.my/200/
• Institution: INTI International University

This study investigated the anti-inflammatory potential of the alcohol extract of Achyranthes aspera Linn. (Amaranthaceae) in Wistar rats after oral administration (50, 100, and 200 mg/kg). This was done using the carrageenan-induced paw edema method (acute inflammatory model) and cotton pellet granuloma test (chronic inflammatory model). The alcohol extract showed significant suppressed granuloma formation. Collectively, these data demonstrate promising anti-inflammatory activity against both acute and chronic inflammation. In addition, inhibition of prostaglandins and bradykinins may play a role. This study reveal- ing the promising anti-inflammatory activity of Achyranthes aspera roots has been carried out scientifically for the first time.