Comparative study on membrane solubilisation of biosynthesized nano-silver & biosynthesized nano-zinc oxide on selected sperm parameter

• Main Authors: Nur Hilwani Ismail, Mohammad Luqman Zulkipli, Helmi Khusairi Baharudin, Nurul Husna Rifin, Rabiatuladawiyah Md. Akhir
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2015
• Online Access: http://journalarticle.ukm.my/10345/1/44_1_11.pdf; http://journalarticle.ukm.my/10345/; http://www.mabjournal.com/index.php?option=com_content&view=article&id=520&catid=59:current-view&Itemid=56
• Institution: Universiti Kebangsaan Malaysia

Extensive applications of nanoparticles are used in the field of catalysis, biosensing, imaging, drug delivery, nano-device fabrication and medicine. Previously, biosynthesized nano-silver and biosynthesized nano-zinc oxide has shown significant effect as antimicrobial agents, thus reduces concern over the threat of antibiotic resistance. Biosynthesis of nano-silver and nano-zinc oxide using Pandanus amaryllifolius leaf extract and their spermicidal effect was explored in the present research following characterization using FESEM-EDX and were determined to be spherical in shape and aggregated into regular structure with high uniformity. The sperm membrane solubilisation property displayed by both biosynthesized nano-silver and biosynthesized nano-zinc oxide exceeded the effects of 1% (w/v) Triton-X and was most significant at the concentration of 100 μg/ml. The results suggested that biosynthesized nano-silver and biosynthesized nano-zinc oxide holds possibility as new generation spermicidal agents.