Impact of nitric oxide synthase 2 gene variant on risk of anti-tuberculosis drug- induced liver injury in the Malaysian population

• Main Authors: Vishala Sivapalan, Shamsul Mohd Zain, Jin, Shengnan, Chan, Sze Ling, Liu, Jiajun, Zahurin Mohamed, Rosmawati Mohamed
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2020
• Online Access: http://journalarticle.ukm.my/14756/1/ARTIKEL%202.pdf; http://journalarticle.ukm.my/14756/; http://www.ukm.my/jsm/malay_journals/jilid49bil2_2020/KandunganJilid49Bil2_2020.html
• Institution: Universiti Kebangsaan Malaysia

Liver injury is a great threat associated with anti-tuberculosis (anti-TB) medication. Genetic variations in genes encoding drug-metabolising enzymes further enhance this threat. We aimed to explore genetic contributions by evaluating the impact of single nucleotide polymorphisms (SNPs) within the a...