Detection of BCR-ABL T315i mutation in imatinib resistant chronic myeloid leukemia patients

• Main Authors: Mardziah M, Salwati Shuib, Azlin Ithnin, Hafiza Alauddin, Noor Farisah AR, Noraesah M, Tumian NR, Wong, CL, Raja Zahratul Azma Raja Sabudin
• Format: Article
• Language: English
• Published: Pusat Perubatan Universiti Kebangsaan Malaysia 2019
• Online Access: http://journalarticle.ukm.my/15220/1/12_ms0293_pdf_83778.pdf; http://journalarticle.ukm.my/15220/; http://www.medicineandhealthukm.com/toc/14/1
• Institution: Universiti Kebangsaan Malaysia

Chronic myeloid leukemia (CML) patients who have BCR-ABL T315I mutation, usually present in the advance phase of the disease with overall survival (OS) shorter than those without the mutation. This study aimed to determine the prevalence of T315I mutation amongst imatinib mesylate (IM) resistant CML...