Potential association of nicotinamide on the telomerase activity and telomere length mediated by PARP-1 mechanism in myeloid cancer

• Main Authors: Nur Rasyidah Muhammad, Azlina Ahmad, Siti Norasikin Mohd Nafi, Farizan Ahmad, Zariyantey Abdul Hamid, Sarina Sulong
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2020
• Online Access: http://journalarticle.ukm.my/15355/1/13.pdf; http://journalarticle.ukm.my/15355/; http://www.ukm.my/jsm/malay_journals/jilid49bil4_2020/KandunganJilid49Bil4_2020.html
• Institution: Universiti Kebangsaan Malaysia

Administration of nicotinamide is affecting various types of cells through its survival, maturation, and differentiation. Nicotinamide as part of vitamin B3, plays an important role in DNA repair and maintenance of the genomic stability which related to its function as a NAD+ precursor that involve...