Design, synthesis and biological evaluation of aminoalkylated chalcones as antimalarial agent

• Main Authors: Syahri, Jufrizal, Nasution, Hasmalina, Nurohmah, Beta Achromi, Purwono, Bambang, Emmy Yuanita, Nur Hanis Zakaria, Nurul Izzaty Hassan
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2020
• Online Access: http://journalarticle.ukm.my/15997/1/6.pdf; http://journalarticle.ukm.my/15997/; https://www.ukm.my/jsm/malay_journals/jilid49bil11_2020/KandunganJilid49Bil11_2020.html
• Institution: Universiti Kebangsaan Malaysia

Aminoalkylated chalcone compounds (4a-4c) have been designed using Quantitative Structure-Activity Relationship (QSAR) analysis, synthesized and evaluated for their in vitro antimalarial activity. The best QSAR model obtained was log IC50 = 705.132 (qC7) - 65.573 (qC3) - 24.845 (qC4) - 4.634 (qC13...