The efficacy of prophylactic intravenous granisetron in preventing post anaesthesia shivering in gynaecological patients undergoing surgery under general anaesthesia
Post-anaesthetic shivering is one of the commonest complications during emergence from general anaesthesia with the rate of occurrence between 5 to 65%. It increases oxygen consumption and carbon dioxide production resulting in delayed recovery from anaesthesia and other adverse events. Granis...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/17434/1/3_ms0439_pdf_10200.pdf http://journalarticle.ukm.my/17434/ https://www.medicineandhealthukm.com/toc/16/1 |
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| Institution: | Universiti Kebangsaan Malaysia |
| Language: | English |
| Summary: | Post-anaesthetic shivering is one of the commonest complications during
emergence from general anaesthesia with the rate of occurrence between 5 to
65%. It increases oxygen consumption and carbon dioxide production resulting
in delayed recovery from anaesthesia and other adverse events. Granisetron is
one of the drugs used to prevent post-anaesthetic shivering. This prospective,
double-blind and randomised control study compared the efficacy of prophylaxis
IV granisetron at 2 mg and 3 mg doses in preventing post-anaesthetic shivering.
There were 104 patients, ASA I and II scheduled for elective open gynaecological
surgery recruited and randomised into 2 groups: Group A and B, receiving 2
and 3 mg of IV granisetron, resepectively. Intravenous anaesthetic drugs were
administered and tracheal intubation was facilitated by muscle paralysis. Patients’
baseline and periodic tympanic core temperatures were measured perioperatively.
The incidence and severity of shivering were assessed postoperatively using
Wrench Scoring Classification whereby Group A and B had 8.3% and 16.7% of
incidence, respectively, in which they were not statistically significant (p = 0.199).
All patients from both groups who shivered experienced Grade 1 shivering except
for one patient who registered a Grade 2 in Group B. None of our patients had
Grade 3 or 4 shivering postoperatively. No one experienced nausea or vomiting
in the recovery area. Prophylactic IV granisetron of 2 mg and 3 mg were equally
effective in reducing the incidence and severity of post-anaesthetic shivering in
gynaecological patients undergoing surgery under general anaesthesia with no
unpleasant side effects. |
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