Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model

Sleep deprivation has been shown to alter pain responses in humans and animals. The present study investigated whether the administration of Tualang honey in the rapid eye movement (REM) sleep deprivation rat model would modulate nociceptive responses with associated changes in the thalamus. Forty...

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Main Authors: Anis Syahirah Mohd Shafie, Che Badariah Abd Aziz, Liza Noordin, Idris Long, Anani Aila Mat Zin, Rosfaiizah Siran
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2021
Online Access:http://journalarticle.ukm.my/18879/1/039-047%2B%2B%2BChe%2BBadariah%2BAbd%2BAziz.pdf
http://journalarticle.ukm.my/18879/
https://jms.mabjournal.com/index.php/mab/issue/view/43
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Institution: Universiti Kebangsaan Malaysia
Language: English
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spelling my-ukm.journal.188792022-07-05T07:38:35Z http://journalarticle.ukm.my/18879/ Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model Anis Syahirah Mohd Shafie, Che Badariah Abd Aziz, Liza Noordin, Idris Long, Anani Aila Mat Zin, Rosfaiizah Siran, Sleep deprivation has been shown to alter pain responses in humans and animals. The present study investigated whether the administration of Tualang honey in the rapid eye movement (REM) sleep deprivation rat model would modulate nociceptive responses with associated changes in the thalamus. Forty-eight Sprague Dawley male rats were randomised into four groups (n=12 for each group): control group (FMC), REM sleep deprivation (REMsd), REM sleep deprivation pretreated with Tualang Honey for 1 month (REMsdH) and tank control (TC). Following sleep deprivation for 72 hours, a formalin test was conducted and pain behaviour was recorded and analysed. The rats were sacrificed, and the brains were removed for histological examination and assessment of N-methyl-D-aspartate receptor (NMDA R2) level in the thalamus. REMsdH group showed a significantly lower level of pain behaviour score and NMDA R2 compared to the REMsd group (p<0.05). In addition, REMsdH also demonstrated a significantly higher number of Nissl stained neurons in comparison with the REMsd group (p<0.05). Furthermore, dark neurons, suggestive of neuronal damage, were observed in the REMsd group. In conclusion, administration of Tualang honey before REM sleep deprivation modulated nociceptive responses and prevent changes in thalamic neurons and NMDA R2 level. Penerbit Universiti Kebangsaan Malaysia 2021 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/18879/1/039-047%2B%2B%2BChe%2BBadariah%2BAbd%2BAziz.pdf Anis Syahirah Mohd Shafie, and Che Badariah Abd Aziz, and Liza Noordin, and Idris Long, and Anani Aila Mat Zin, and Rosfaiizah Siran, (2021) Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model. Malaysian Applied Biology, 50 (3). pp. 39-47. ISSN 0126-8643 https://jms.mabjournal.com/index.php/mab/issue/view/43
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Sleep deprivation has been shown to alter pain responses in humans and animals. The present study investigated whether the administration of Tualang honey in the rapid eye movement (REM) sleep deprivation rat model would modulate nociceptive responses with associated changes in the thalamus. Forty-eight Sprague Dawley male rats were randomised into four groups (n=12 for each group): control group (FMC), REM sleep deprivation (REMsd), REM sleep deprivation pretreated with Tualang Honey for 1 month (REMsdH) and tank control (TC). Following sleep deprivation for 72 hours, a formalin test was conducted and pain behaviour was recorded and analysed. The rats were sacrificed, and the brains were removed for histological examination and assessment of N-methyl-D-aspartate receptor (NMDA R2) level in the thalamus. REMsdH group showed a significantly lower level of pain behaviour score and NMDA R2 compared to the REMsd group (p<0.05). In addition, REMsdH also demonstrated a significantly higher number of Nissl stained neurons in comparison with the REMsd group (p<0.05). Furthermore, dark neurons, suggestive of neuronal damage, were observed in the REMsd group. In conclusion, administration of Tualang honey before REM sleep deprivation modulated nociceptive responses and prevent changes in thalamic neurons and NMDA R2 level.
format Article
author Anis Syahirah Mohd Shafie,
Che Badariah Abd Aziz,
Liza Noordin,
Idris Long,
Anani Aila Mat Zin,
Rosfaiizah Siran,
spellingShingle Anis Syahirah Mohd Shafie,
Che Badariah Abd Aziz,
Liza Noordin,
Idris Long,
Anani Aila Mat Zin,
Rosfaiizah Siran,
Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model
author_facet Anis Syahirah Mohd Shafie,
Che Badariah Abd Aziz,
Liza Noordin,
Idris Long,
Anani Aila Mat Zin,
Rosfaiizah Siran,
author_sort Anis Syahirah Mohd Shafie,
title Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model
title_short Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model
title_full Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model
title_fullStr Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model
title_full_unstemmed Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model
title_sort tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2021
url http://journalarticle.ukm.my/18879/1/039-047%2B%2B%2BChe%2BBadariah%2BAbd%2BAziz.pdf
http://journalarticle.ukm.my/18879/
https://jms.mabjournal.com/index.php/mab/issue/view/43
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