Coconut oil and cholesterol as challenge agents to induce hyperlipidemia and atherosclerosis in hamster animal model
Hyperlipidemia is a condition of high lipid levels in the plasma and often linked with the deposition of lipid droplets in the aorta which initiate the progression of atherosclerosis. Atherosclerosis is a common cardiovascular disorder initiated by the formation of foams cells in the vascular wal...
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Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2018
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Online Access: | http://journalarticle.ukm.my/20198/1/5_ms395_pdf_15764.pdf http://journalarticle.ukm.my/20198/ https://www.medicineandhealthukm.com/toc/13/1 |
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Institution: | Universiti Kebangsaan Malaysia |
Language: | English |
Summary: | Hyperlipidemia is a condition of high lipid levels in the plasma and often linked
with the deposition of lipid droplets in the aorta which initiate the progression of
atherosclerosis. Atherosclerosis is a common cardiovascular disorder initiated by
the formation of foams cells in the vascular wall which leads to turbulent blood
flow, injury to the endothelial layer and subsequent vascular thrombosis. Since
the early 1980’s, Golden-Syrian hamsters have been widely used as an animal
model in the research of hyperlipidemia and atherosclerosis. The use of hamsters
in the hyperlipidemic and atherosclerotic model is due to their lipoprotein profile
that is closer to human setting, sensitive to high-fat high-cholesterol (HFHC) diet
and a suitable rodent model. Atherosclerosis can be induced in hamsters through
dietary challenge with HFHC diet. Over the decades, coconut oil (CNO) was
commonly used as the source of fat in the diet design of high saturated fatty acids
(SFA) composition. In this review, we summarized published literature with designs
involving CNO plus cholesterol-induced hyperlipidemia, atherosclerosis or both.
The factors that may influence the ability of CNO and cholesterol combination to
induce hyperlipidemia such as the period of dietary intervention, hamster strains
and the dietary amount were evaluated and summarized. |
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