Substituted 3-styryl-2-pyrazoline derivatives as an antimalaria : synthesis, in vitro assay, molecular docking, druglikeness analysis, and ADMET prediction

• Main Authors: Linda Ekawati, Beta Achromi Nurohmah, Syahri, Jufrizal, Purwono, Bambang
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2022
• Online Access: http://journalarticle.ukm.my/20867/1/9.pdf; http://journalarticle.ukm.my/20867/; https://www.ukm.my/jsm/malay_journals/jilid51bil10_2022/KandunganJilid51Bil10_2022.html
• Institution: Universiti Kebangsaan Malaysia

The synthesis, in vitro antimalarial assay, molecular docking, drug-likeness analysis, and ADMET prediction of substituted 3-styryl-2-pyrazoline derivatives as antimalaria have been conducted. The synthesis of N-phenyl (1a‒3a) and N-acetyl-substituted (1b‒3b) 3-styryl-2-pyrazolines was carried o...