Dimethyloxalylglycine (DMOG)-induced hypoxia promotes migratory and invasive properties of HCT116 colon cancer cell line

• Main Authors: Nor Ezleen Qistina Ahmad, Amirah Alhusna Mohd Yusoff, Nur Fariesha Md Hashim, Nurul Akmaryanti Abdullah, Noraina Muhamad Zakuan
• Format: Article
• Language: English
• Published: Universiti Kebangsaan Malaysia 2024
• Online Access: http://journalarticle.ukm.my/24123/1/SME%209.pdf; http://journalarticle.ukm.my/24123/; https://www.ukm.my/jsm/english_journals/vol53num6_2024/contentsVol53num6_2024.html
• Institution: Universiti Kebangsaan Malaysia

Hypoxia, a condition characterised by low oxygen levels, leads to increased production of a protein called hypoxiainducible factor-1 alpha (HIF-1α) in cancer cells. This protein is involved in driving processes such as vascularization, cytoskeletal reorganisation, and epithelial-to-mesenchymal trans...