Differential protein expression in senescent human skin fibroblasts and stress induced premature senescence (SIPS) fibroblasts

• Main Authors: Goon Jo Aan, Haryati Ahmad Hairi, Suzana Makpol, Mariati Abdul Rahman, Saiful Anuar Karsani, Wan Zurinah Wan Ngah
• Format: Article
• Language: English
• Published: Universiti Kebangsaan Malaysia 2011
• Online Access: http://journalarticle.ukm.my/2935/1/07_Haryati.pdf; http://journalarticle.ukm.my/2935/; http://www.ukm.my/jsm/contents.html
• Institution: Universiti Kebangsaan Malaysia

Replicative senescence of human diploid fibroblasts (HDFs) occurs when cells lose their capacity to proliferate and enter a phase of irreversible growth arrest. Stress-induced premature senescence (SIPS) on the other hand is caused by subcytotoxic concentrations of various oxidants which trigger acc...