Kesan in vitro rilmenidine ke atas rembesan insulin

• Main Authors: Rosnani Hashim, Tariq Abdul Razak, Suhaimi Hashim
• Format: Article
• Language: English
• Published: penerbit ukm 2003
• Online Access: http://journalarticle.ukm.my/948/1/jurnal4.pdf; http://journalarticle.ukm.my/948/; http://www.fskb.ukm.my/fskbold/jurnal
• Institution: Universiti Kebangsaan Malaysia

This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak plasma concentration achieved with an oral dose of 1 mg. T a low concentration, Rilmenidine (0.35 ng/ml) significantly stimulated insulin secretion (p‹0.01). However, Rilmenidine showed a significantly weak inhibition (p< 0.05) at 3.5 ng/ml and a strong inhibitin at a higher concentration (35.0 ng/ml). The result showed that Rilmenidine exhibited significant stimulating and inhibitory effects on insulin secretion from the pancreas at different concentrations.