Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations

Anemia of chronic disease (ACD) frequently occurred in patients with chronic inflammatory diseases and can be treated by treating the underlying disease. On the other hand, iron-deficiency anemia (IDA), the most common type of anemia, occurred with iron loss or when the iron requirement of the body...

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Main Authors: Eun, Suk Yang, Yu, Seop Kim, Chan, Young Park, Jong, Dae Kim, Hye, Jeong Song
Format: Article
Language:English
Published: Universiti Kebangsaan Malaysia 2015
Online Access:http://journalarticle.ukm.my/9485/1/01_Eun-Suk_Yang.pdf
http://journalarticle.ukm.my/9485/
http://www.ukm.my/jsm/english_journals/vol44num12_2015/contentsVol44num12_2015.html
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Institution: Universiti Kebangsaan Malaysia
Language: English
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spelling my-ukm.journal.94852016-12-14T06:50:04Z http://journalarticle.ukm.my/9485/ Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations Eun, Suk Yang Yu, Seop Kim Chan, Young Park Jong, Dae Kim Hye, Jeong Song Anemia of chronic disease (ACD) frequently occurred in patients with chronic inflammatory diseases and can be treated by treating the underlying disease. On the other hand, iron-deficiency anemia (IDA), the most common type of anemia, occurred with iron loss or when the iron requirement of the body was increased. Since the treatment methods for ACD and IDA differ, it is important to clinically distinguish between the two types of anemia. In this study, we investigated and evaluated the performance of a number of biomarkers, including ferritin, soluble transferrin receptor (sTfR), hepcidin, C-reactive protein (CRP) and combination markers containing ferritin for the diagnosis of IDA using serum samples from Korean patients (80 ACD and 48 IDA Korean patients). Among the single markers, ferritin exhibited the best performance with 98.58% AUC and 97.50% sensitivity. In this study, a combination of two biomarkers was used to differentially diagnose IDA and ACD. Among the combination markers, ferritin + sTfR showed the best performance with 99.51% AUC and 98.75% sensitivity. We found that the ferritin + sTfR combination showed the best diagnostic performance with 1.25% higher SN than ferritin alone. Moreover, it also showed 10% better diagnostic performance than the single ferritin marker within the data range where the distinction between ACD and IDA is unclear. We propose that using combination markers containing ferritin may diagnose IDA more accurately and facilitate the determination of the appropriate anemia treatment to expedite patient recovery. Universiti Kebangsaan Malaysia 2015-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9485/1/01_Eun-Suk_Yang.pdf Eun, Suk Yang and Yu, Seop Kim and Chan, Young Park and Jong, Dae Kim and Hye, Jeong Song (2015) Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations. Sains Malaysiana, 44 (12). pp. 1653-1659. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol44num12_2015/contentsVol44num12_2015.html
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Anemia of chronic disease (ACD) frequently occurred in patients with chronic inflammatory diseases and can be treated by treating the underlying disease. On the other hand, iron-deficiency anemia (IDA), the most common type of anemia, occurred with iron loss or when the iron requirement of the body was increased. Since the treatment methods for ACD and IDA differ, it is important to clinically distinguish between the two types of anemia. In this study, we investigated and evaluated the performance of a number of biomarkers, including ferritin, soluble transferrin receptor (sTfR), hepcidin, C-reactive protein (CRP) and combination markers containing ferritin for the diagnosis of IDA using serum samples from Korean patients (80 ACD and 48 IDA Korean patients). Among the single markers, ferritin exhibited the best performance with 98.58% AUC and 97.50% sensitivity. In this study, a combination of two biomarkers was used to differentially diagnose IDA and ACD. Among the combination markers, ferritin + sTfR showed the best performance with 99.51% AUC and 98.75% sensitivity. We found that the ferritin + sTfR combination showed the best diagnostic performance with 1.25% higher SN than ferritin alone. Moreover, it also showed 10% better diagnostic performance than the single ferritin marker within the data range where the distinction between ACD and IDA is unclear. We propose that using combination markers containing ferritin may diagnose IDA more accurately and facilitate the determination of the appropriate anemia treatment to expedite patient recovery.
format Article
author Eun, Suk Yang
Yu, Seop Kim
Chan, Young Park
Jong, Dae Kim
Hye, Jeong Song
spellingShingle Eun, Suk Yang
Yu, Seop Kim
Chan, Young Park
Jong, Dae Kim
Hye, Jeong Song
Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations
author_facet Eun, Suk Yang
Yu, Seop Kim
Chan, Young Park
Jong, Dae Kim
Hye, Jeong Song
author_sort Eun, Suk Yang
title Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations
title_short Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations
title_full Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations
title_fullStr Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations
title_full_unstemmed Improvement in the diagnostics of iron deficiency anemia using multiple marker combinations
title_sort improvement in the diagnostics of iron deficiency anemia using multiple marker combinations
publisher Universiti Kebangsaan Malaysia
publishDate 2015
url http://journalarticle.ukm.my/9485/1/01_Eun-Suk_Yang.pdf
http://journalarticle.ukm.my/9485/
http://www.ukm.my/jsm/english_journals/vol44num12_2015/contentsVol44num12_2015.html
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