Peroxisome Proliferactor Activated Receptor Gamma (PPAR-γ) Polymorphism Towards Obesity Endemic in Malaysia
Obesity is pandemic and its associated co-morbidities, nowdays pose a major threat to global health systems. Obesity is often associated with adipose tissue dysfunction in which adiposity hypertrophy, adipose tissue hypo-perfusion and hypoxia, adipose tissue inflammation and macrophage infiltratio...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | http://eprints.unisza.edu.my/4390/1/FH02-FPSK-14-00709.pdf http://eprints.unisza.edu.my/4390/ |
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| Institution: | Universiti Sultan Zainal Abidin |
| Language: | English |
| Summary: | Obesity is pandemic and its associated co-morbidities, nowdays pose a major threat to global health systems.
Obesity is often associated with adipose tissue dysfunction in which adiposity hypertrophy, adipose tissue hypo-perfusion and hypoxia, adipose tissue inflammation and macrophage infiltration are interrelated with each other
in the pathophysiology and pathogenesis of obesity. Here we will discuss how genetic studies, through the discovery
of peroxisome proliferactor-activated receptor gamma (PPAR-γ) have contributed to our understanding of the
central pathways which govern the mechanism of how obesity develops in human. In Malaysia, we are still lacking
information about the interaction of PPAR-γ polymorphism with obesity. We anticipate that future studies should
emphasize more on genetic research, especially on lipid studies so that we could develop a most efficient and
achievable targeted approach to the prevention and control of obesity accordingly. |
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