Adverse Drug Reactions: Predisposing Factors, Modern Classifications and Causality Assessment
Several factors predispose patient to develop adverse drug reactions (ADRs), some of these factors are drug related, patient related, disease related, social and adverse drug related. The contributions of these factors to development of ADRs are very crucial and are well documented in medical lite...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English English |
| Published: |
2014
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| Subjects: | |
| Online Access: | http://eprints.unisza.edu.my/5651/1/FH02-FP-15-03031.pdf http://eprints.unisza.edu.my/5651/2/FH02-FP-16-05368.jpg http://eprints.unisza.edu.my/5651/ |
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| Institution: | Universiti Sultan Zainal Abidin |
| Language: | English English |
| Summary: | Several factors predispose patient to develop adverse drug reactions (ADRs), some of these factors are drug related,
patient related, disease related, social and adverse drug related. The contributions of these factors to development of
ADRs are very crucial and are well documented in medical literature. It has become necessary for every medical
practitioner to consider these factors in order to prescribe the best medication to his patients. The current classification
of ADRs is only based on drug known pharmacology and dose dependent of its action. In order to give comprehensive
classification, the time course of its appearance and its severity as well as patient susceptibility are taken into
consideration. Knowledge of causality assessment enables the medical practitioners to clarify the likelihood that the
suspected adverse drug reaction is actually due to the medicine. This requires careful patient monitoring because
adverse drug reaction can be difficult and a times impossible to distinguish from patient disease condition. The
purpose of this article is to review the factors affecting the development of ADRs, its broader classification and to
assess causal relationship between the suspected drug and appearance of ADRs. |
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