Study of association of TGF-B1 polymorphism with breast density in a tertiary medical center of Malaysia
Early detection of breast cancer risk by screening tools such as mammography can reduces the cost of treatment management and the prognosis of the disease. The level of breast density of in mammogram is one of the potential cofounder factor for breast cancer risk. The development of mammary epith...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2017
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| Subjects: | |
| Online Access: | http://eprints.unisza.edu.my/5681/1/FH02-ICODE-18-12612.pdf http://eprints.unisza.edu.my/5681/ |
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| Institution: | Universiti Sultan Zainal Abidin |
| Language: | English |
| Summary: | Early detection of breast cancer risk by screening tools such as mammography can
reduces the cost of treatment management and the prognosis of the disease. The
level of breast density of in mammogram is one of the potential cofounder factor
for breast cancer risk. The development of mammary epithelial cells is determined
by the genetic factor. Transforming growth factor-beta (TGF-ß) gene involves in
the regulation of cell proliferation and cell division. This study aimed to assess the
association of TGF-ß1 polymorphisms with breast density among women who
underwent breast screening using mammogram. The detection of genotypes for
three polymorphisms of TGF-ß1 assigned as rs1800469, rs1800470 and rs4803455
were performed using PCR-RFLP technique. The allele and genotype frequencies
were calculated for control group that consists of BIRADS 1 and BIRADS 2 class
whilst case group consisted of BIRADS 3 and BIRADS 4 class. Two polymorphisms
(rs1800469 and rs1800470) yielded a significant association with breast density
with p value of 0.004 and 0.003, respectively. However, the third polymorphism,
rs4803455 did not yield a significant association (p value=0.090). Haplotype
association analysis might suggest the haplotype GAA conferred susceptibility (p
value= 0.02, OR=2.21[1.07-4.55]) rather than haplotype AAC predispose a protective
effect (p value=0.004, OR=0.40[0.21-0.77]) to breast density development. This
preliminary data on single and haplotype association might reveal the association
of polymorphisms of TGF-ß1 with breast density and give an insight on the role of
polymorphism in predisposing to breast density development. |
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