Comparative analysis of the antibacterial, antifungal, antiproliferative and cyclic response element (CRE) induced expression of downstream luc gene activities of Monopterus albus and Channa straitus extracts
In Malaysia, Monopterus albus is commonly found in rice fields, muddy ponds and swamp areas. Channa striatus have been widely used as a source of traditional medicines. The extracts of Malaysian local Monopterus albus and Channa straitus have been reported to have different bioactive properties an...
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Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Open Science Publishers LLP Inc.
2015
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Subjects: | |
Online Access: | http://eprints.unisza.edu.my/5851/1/FH02-FPSK-15-02635.jpg http://eprints.unisza.edu.my/5851/ |
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Institution: | Universiti Sultan Zainal Abidin |
Language: | English |
Summary: | In Malaysia, Monopterus albus is commonly found in rice fields, muddy ponds and swamp areas. Channa
striatus have been widely used as a source of traditional medicines. The extracts of Malaysian local
Monopterus albus and Channa straitus have been reported to have different bioactive properties and these
properties can be used at molecular level as alternative tool for different disorders. The comparative analysis
of antibacterial, antifungal, antiproliferative and CRE induced expression of downstream luc gene activities
of both the extracts were performed. The bacteriostatic and antibacterial effects of both extracts were
revealed beside higher antifungal activity of Channa straitus. The extracts from Monopterus albus showed
higher levels of antiproliferative activity as compare to Channastraitus. The results were found supportive
towards up regulation of hrluc by Monopterus albus extracts and down regulation by Channa striatus
extracts. This is the first report on comparing the bioactive properties of Monopterus albus and Channa
straitus. The results from this study demands a further research on identifying the bioactive molecules
involve in these actions at a molecular level. |
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