The effect of flax seed extract on the blood glucose level and liver bio markers in diabetic rats
Prescribed medications used to treat diabetes do not adequately inhibit the development of its associated complications, furthermore, they may cause different side effects. Hence, there is a demand for alternative therapies to manage diabetes and its associated complications. This study aimed to...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
2019
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| Subjects: | |
| Online Access: | http://eprints.unisza.edu.my/6283/1/FH02-FP-19-26715.pdf http://eprints.unisza.edu.my/6283/ |
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| Institution: | Universiti Sultan Zainal Abidin |
| Language: | English |
| Summary: | Prescribed medications used to treat diabetes do not adequately inhibit
the development of its associated complications, furthermore, they may
cause different side effects. Hence, there is a demand for alternative
therapies to manage diabetes and its associated complications. This
study aimed to evaluate the hepatoprotective effects of flaxseed extract
in streptozotocin(STZ)-induced diabetic rats. Diabetes mellitus was
induced in Sprague-Dawley rats using a single injection of
streptozotocin (60 mg/kg, intraperitoneally). The rats were divided into
five groups of 8 animals each: Group NC, normal control rats; Group
NF, normal rats treated with flaxseed extract (400 mg/kg); Group DC,
diabetic control rats; Group DG, diabetic rats treated with
glibenclamide (0.6 mg/kg); Group DF, diabetic rats treated with flaxseed extract (400
mg/kg); for 4 weeks. Body weight, liver relative weight, blood glucose level and liver
enzymes were determined in all experimental rats. Results showed a significantly increased
relative liver weight, blood glucose, AST, ALT, GGT, ALP, and LDH levels, and decreased
body weight, total protein, albumin, and globulin levels in DC group comparing to NC group
(p<0.05). The disturbance of these parameters was ameliorated in DF and DG groups,
however, the ameliorative effect was significant in DG group only (p<0.05). These
pathological changes were ameliorated in the flaxseed extract and glibenclamide treated rats. In conclusion, our data showed that flaxseed extract represents a potential alternative
treatment to control diabetes mellitus and its related hepatopathy. |
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