The effects of Secondhand Smoke (SHS) exposure on microvascular endothelial function among healthy women

Background Studies have demonstrated that secondhand smoke (SHS) exposure could impair endothelial function. However, the effect of SHS exposure specifically on microvascular endothelial function is not well understood. This study aimed to determine the effects of SHS exposure on microvascular endo...

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Main Authors: Harmy, Mohamed Yusoff, Zulkefli, Sanip, Siti Hajar, Mohd Hanaffi
Format: Article
Language:English
English
Published: BioMed Central Ltd. 2015
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spelling my-unisza-ir.66492022-09-13T05:48:40Z http://eprints.unisza.edu.my/6649/ The effects of Secondhand Smoke (SHS) exposure on microvascular endothelial function among healthy women Harmy, Mohamed Yusoff Zulkefli, Sanip Siti Hajar, Mohd Hanaffi QH301 Biology R Medicine (General) Background Studies have demonstrated that secondhand smoke (SHS) exposure could impair endothelial function. However, the effect of SHS exposure specifically on microvascular endothelial function is not well understood. This study aimed to determine the effects of SHS exposure on microvascular endothelial function among non-smoking, generally healthy women. Findings We studied 127 women; and based on their hair nicotine levels measured using gas chromatography-mass spectrometry, 25 of them were categorized as having higher hair nicotine levels, 25 were grouped as having lower hair nicotine and 77 women were grouped into the non-detected group. The non-detected group did not have detectable levels of hair nicotine. Anthropometry, blood pressure (BP), lipid profile and high-sensitivity C-reactive protein (hsCRP) were measured accordingly. Microvascular endothelial function was assessed non-invasively using laser Doppler fluximetry and the process of iontophoresis involving acetylcholine and sodium nitroprusside as endothelium-dependent and endothelium-independent vasodilators respectively. The mean hair nicotine levels for higher and lower hair nicotine groups were 0.74 (1.04) and 0.05 (0.01) ng/mg respectively. There were no significant differences in anthropometry, BP, lipid profile and hsCRP between these groups. There were also no significant differences in the microvascular perfusion and endothelial function between these groups. Conclusion In this study, generally healthy non-smoking women who have higher, lower and non-detected hair nicotine levels did not show significant differences in their microvascular endothelial function. Low levels of SHS exposure among generally healthy non-smoking women may not significantly impair their microvascular endothelial function. BioMed Central Ltd. 2015-09 Article PeerReviewed image en http://eprints.unisza.edu.my/6649/1/FH02-FP-15-03783.jpg image en http://eprints.unisza.edu.my/6649/2/FH02-FP-15-04190.jpg Harmy, Mohamed Yusoff and Zulkefli, Sanip and Siti Hajar, Mohd Hanaffi (2015) The effects of Secondhand Smoke (SHS) exposure on microvascular endothelial function among healthy women. Tobacco Induced Diseases, 13 (1). pp. 1-5. ISSN 16179625
institution Universiti Sultan Zainal Abidin
building UNISZA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sultan Zainal Abidin
content_source UNISZA Institutional Repository
url_provider https://eprints.unisza.edu.my/
language English
English
topic QH301 Biology
R Medicine (General)
spellingShingle QH301 Biology
R Medicine (General)
Harmy, Mohamed Yusoff
Zulkefli, Sanip
Siti Hajar, Mohd Hanaffi
The effects of Secondhand Smoke (SHS) exposure on microvascular endothelial function among healthy women
description Background Studies have demonstrated that secondhand smoke (SHS) exposure could impair endothelial function. However, the effect of SHS exposure specifically on microvascular endothelial function is not well understood. This study aimed to determine the effects of SHS exposure on microvascular endothelial function among non-smoking, generally healthy women. Findings We studied 127 women; and based on their hair nicotine levels measured using gas chromatography-mass spectrometry, 25 of them were categorized as having higher hair nicotine levels, 25 were grouped as having lower hair nicotine and 77 women were grouped into the non-detected group. The non-detected group did not have detectable levels of hair nicotine. Anthropometry, blood pressure (BP), lipid profile and high-sensitivity C-reactive protein (hsCRP) were measured accordingly. Microvascular endothelial function was assessed non-invasively using laser Doppler fluximetry and the process of iontophoresis involving acetylcholine and sodium nitroprusside as endothelium-dependent and endothelium-independent vasodilators respectively. The mean hair nicotine levels for higher and lower hair nicotine groups were 0.74 (1.04) and 0.05 (0.01) ng/mg respectively. There were no significant differences in anthropometry, BP, lipid profile and hsCRP between these groups. There were also no significant differences in the microvascular perfusion and endothelial function between these groups. Conclusion In this study, generally healthy non-smoking women who have higher, lower and non-detected hair nicotine levels did not show significant differences in their microvascular endothelial function. Low levels of SHS exposure among generally healthy non-smoking women may not significantly impair their microvascular endothelial function.
format Article
author Harmy, Mohamed Yusoff
Zulkefli, Sanip
Siti Hajar, Mohd Hanaffi
author_facet Harmy, Mohamed Yusoff
Zulkefli, Sanip
Siti Hajar, Mohd Hanaffi
author_sort Harmy, Mohamed Yusoff
title The effects of Secondhand Smoke (SHS) exposure on microvascular endothelial function among healthy women
title_short The effects of Secondhand Smoke (SHS) exposure on microvascular endothelial function among healthy women
title_full The effects of Secondhand Smoke (SHS) exposure on microvascular endothelial function among healthy women
title_fullStr The effects of Secondhand Smoke (SHS) exposure on microvascular endothelial function among healthy women
title_full_unstemmed The effects of Secondhand Smoke (SHS) exposure on microvascular endothelial function among healthy women
title_sort effects of secondhand smoke (shs) exposure on microvascular endothelial function among healthy women
publisher BioMed Central Ltd.
publishDate 2015
url http://eprints.unisza.edu.my/6649/1/FH02-FP-15-03783.jpg
http://eprints.unisza.edu.my/6649/2/FH02-FP-15-04190.jpg
http://eprints.unisza.edu.my/6649/
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