IN VITRO ANTIVIRAL ACTIVITY OF ORTHOSIPHON STAMINEUS EXTRACT AGAINST DENGUE VIRUS TYPE 2
In this study, Orthosiphon stamineus aqueous leaves extract was tested against dengue virus type 2. Cytotoxicity screening against Vero cells using MTT assay showed that the CC50 values for extract is 5 mg/ml. The antiviral activity towards Dengue virus type 2 (DENV-2) was investigated by observi...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
2018
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| Subjects: | |
| Online Access: | http://eprints.unisza.edu.my/6714/1/FH02-FSK-18-13446.pdf http://eprints.unisza.edu.my/6714/ http://www.jfas.info/index.php/jfas/issue/view/47 |
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| Institution: | Universiti Sultan Zainal Abidin |
| Language: | English |
| Summary: | In this study, Orthosiphon stamineus aqueous leaves extract was tested against dengue virus
type 2. Cytotoxicity screening against Vero cells using MTT assay showed that the CC50
values for extract is 5 mg/ml. The antiviral activity towards Dengue virus type 2 (DENV-2)
was investigated by observing the morphological changes, which were further confirmed the
cellular viability evaluated by MTT technique. The selective indices (SI = CC50 / EC50) for
the extract is 13. These results demonstrate that the extract prepared from O. stamineus
possesses phytochemical compound that was non cytotoxic to the cell with potential antiviral
activity. These species are good candidates for further activity-monitored fractionation to
identify active principles. |
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