Pharmacist role in individualising amikacin dosing in severe renal failure

• Main Authors: Ab Fatah, Ab Rahman, Mochamad, Djunaedi
• Format: Conference or Workshop Item
• Language: English
• Published: 2017
• Subjects: RS Pharmacy and materia medica
• Online Access: http://eprints.unisza.edu.my/877/1/FH03-FF-18-13073.pdf; http://eprints.unisza.edu.my/877/
• Institution: Universiti Sultan Zainal Abidin

Amikacin is an effective aminoglycoside commonly used in the treatment of gram negative bacterial infections. Serum drug concentration monitoring is used to guide dosing while achieving target concentrations. The aim of this report is to describe the importance of properly performed drug concentration monitoring in a patient on amikacin treatment. A 66-year-old woman with chronic renal failure was treated with amikacin for Acinetobacter infection. Initiation of amikacin loading dose of 700 mg resulted in peak drug concentration of about 24.25mg/L.Subsequent dosing was administered with random drug concentration monitoring. Pharmacists in therapetic drug monitoring service should utilize individual pharmacokinetic parameters and suggest appropriate dosing regimen.