Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazole derivatives

• Main Author: Cheng, Yun Ru
• Format: Final Year Project / Dissertation / Thesis
• Published: 2022
• Subjects: QD Chemistry
• Online Access: http://eprints.utar.edu.my/4922/1/fyp_CE_2022_CYR.pdf; http://eprints.utar.edu.my/4922/
• Institution: Universiti Tunku Abdul Rahman

In this project, a 1,2,4-triazole and a series of 1,2,4-triazolo-1,3,4-thiadiazole derivatives have been successfully synthesized. A total of eight 1,2,4-triazolo-1,3,4-thiadiazole derivatives (YR1-YR8) with different R group substituents (R = H, 2-F, 4-F, 2,4-F2, 4-Br, 4-CH3, 4-N(CH3)2 and 4-NO2) were synthesized from 1,2,4-triazole and benzoic acid derivatives via condensation reaction in the presence of phosphoryl chloride (POCl3) as cyclization agent. The percentage yield of 1,2,4-triazole was 31 % whereas the percentage yield of the synthesized 1,2,4-triazolo-1,3,4-thiadiazole derivatives (YR1-YR8) was in the range of 7 – 84 %. The structures of 1,2,4-triazole and a series of 1,2,4-triazolo-1,3,4-thiadiazole derivatives (YR1-YR8) were characterized and elucidated by using FTIR, 1H NMR, 13C NMR, DEPT, HMQC, HMBC and melting point apparatus.