Synthesizing and Characterization of Amino Acid Based Ionic Liquids for Pharmaceutical Applications

• Main Author: Yazdani, Arash
• Format: Final Year Project
• Language: English
• Published: IRC 2015
• Subjects: TP Chemical technology
• Online Access: http://utpedia.utp.edu.my/16322/1/FYPII-SEP2015-Arash%20Yazdani-17043.pdf; http://utpedia.utp.edu.my/16322/
• Institution: Universiti Teknologi Petronas

There has been a growing attention towards amino acid based ionic liquids (AAILs) since the past decade. Synthesizing ionic liquids (ILs) from renewable biomaterials is a promising method to improve the biocompatibility and biodegradability of ionic liquids. In this project, 10 choline based ILs were synthesized with different amino acids and tested towards gram-positive and gram-negative bacteria to show the relationship between the anion structure and the degree of toxicity. All the AAILs demonstrated a high biocompatibility towards the tested bacteria and their toxicity decreased by smaller molecular size of anion. Additionally, biodegradability of the synthesized AAILs were assessed via the method of closed bottle test employing river water microorganisms and it turned out that all the AAILs had over 60% biodegradation which classifies them as “readily biodegradable”. Longer chain length and presence of functional groups in the structure of anion directly affected the molecular breakdown by microbial activities.