DNA methylation and copy number variation of the complement C4A gene in Schizophrenia

• Main Authors: Abdull Jalil, Mohd Asyraf, Abd. Rahim, Nour El Huda, Mohd Noor, Hanisah, Harun, Noorul Amilin, A. Talib, Norlelawati
• Format: Article
• Language: English; English
• Published: Elsevier 2022
• Subjects: QH426 Genetics; QR180 Immunology; RC321 Neuroscience. Biological psychiatry. Neuropsychiatry
• Online Access: http://irep.iium.edu.my/101531/7/103531_DNA%20methylation%20and%20copy%20number%20variation%20of%20the%20complement.pdf; http://irep.iium.edu.my/101531/8/101531_DNA%20methylation%20and%20copy%20number%20variation_SCOPUS.pdf; http://irep.iium.edu.my/101531/; https://www.sciencedirect.com/science/article/pii/S2452014422002102
• Institution: Universiti Islam Antarabangsa Malaysia

The complement gene C4A has been implicated in schizophrenia through genome-wide association studies (GWAS) and, in vitro and animal studies. However, few studies have examined epigenetic modification of the C4A gene in schizophrenia. We hypothesized that DNA methylation levels of the C4A gene are a...