Neurodegeneration and inflammation crosstalk: therapeutic targets and perspectives
Glia, which was formerly considered to exist just to connect neurons, now plays a key function in a wide range of physiological events, including formation of memory, learning, neuroplasticity, synaptic plasticity, energy consumption, and homeostasis of ions. Glial cells regulate the brain's im...
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my.iium.irep.1020442023-02-20T06:33:13Z http://irep.iium.edu.my/102044/ Neurodegeneration and inflammation crosstalk: therapeutic targets and perspectives Mohamed, Wael Mohamed Yousef Kumar, Jaya S.Alghamdi, Badrah Soliman, Al-Hassan Toshihide, Yamashita R Medicine (General) Glia, which was formerly considered to exist just to connect neurons, now plays a key function in a wide range of physiological events, including formation of memory, learning, neuroplasticity, synaptic plasticity, energy consumption, and homeostasis of ions. Glial cells regulate the brain's immune responses and confers nutritional and structural aid to neurons, making them an important player in a broad range of neurological disorders. Alzheimer's, ALS, Parkinson's, frontotemporal dementia (FTD), and epilepsy are a few of the neurodegenerative diseases that have been linked to microglia and astroglia cells, in particular. Synapse growth is aided by glial cell activity, and this activity has an effect on neuronal signalling. Each glial malfunction in diverse neurodegenerative diseases is distinct, and we will discuss its significance in the progression of the illness, as well as its potential for future treatment Elsevier 2022-12-16 Article PeerReviewed application/pdf en http://irep.iium.edu.my/102044/1/IBRO_REPORT_1-s2.0-S2667242122000999-main.pdf application/pdf en http://irep.iium.edu.my/102044/7/102044_Neurodegeneration%20and%20inflammation%20crosstalk_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/102044/8/102044_Neurodegeneration%20and%20inflammation%20crosstalk.pdf Mohamed, Wael Mohamed Yousef and Kumar, Jaya and S.Alghamdi, Badrah and Soliman, Al-Hassan and Toshihide, Yamashita (2022) Neurodegeneration and inflammation crosstalk: therapeutic targets and perspectives. IBRO Neuroscience Reports, 14. pp. 95-110. ISSN 2667-2421 https://www.sciencedirect.com/science/article/pii/S2667242122000999/pdfft?md5=b1870afb63f84e2876d68c70cf7df0c0&pid=1-s2.0-S2667242122000999-main.pdf https://doi.org/10.1016/j.ibneur.2022.12.003 |
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Glia, which was formerly considered to exist just to connect neurons, now plays a key function in a wide range of physiological events, including formation of memory, learning, neuroplasticity, synaptic plasticity, energy consumption, and homeostasis of ions. Glial cells regulate the brain's immune responses and confers nutritional and structural aid to neurons, making them an important player in a broad range of neurological disorders. Alzheimer's, ALS, Parkinson's, frontotemporal dementia (FTD), and epilepsy are a few of the neurodegenerative diseases that have been linked to microglia and astroglia cells, in particular. Synapse growth is aided by glial cell activity, and this activity has an effect on neuronal signalling. Each glial malfunction in diverse neurodegenerative diseases is distinct, and we will discuss its significance in the progression of the illness, as well as its potential
for future treatment |
format |
Article |
author |
Mohamed, Wael Mohamed Yousef Kumar, Jaya S.Alghamdi, Badrah Soliman, Al-Hassan Toshihide, Yamashita |
author_facet |
Mohamed, Wael Mohamed Yousef Kumar, Jaya S.Alghamdi, Badrah Soliman, Al-Hassan Toshihide, Yamashita |
author_sort |
Mohamed, Wael Mohamed Yousef |
title |
Neurodegeneration and inflammation crosstalk: therapeutic targets and perspectives |
title_short |
Neurodegeneration and inflammation crosstalk: therapeutic targets and perspectives |
title_full |
Neurodegeneration and inflammation crosstalk: therapeutic targets and perspectives |
title_fullStr |
Neurodegeneration and inflammation crosstalk: therapeutic targets and perspectives |
title_full_unstemmed |
Neurodegeneration and inflammation crosstalk: therapeutic targets and perspectives |
title_sort |
neurodegeneration and inflammation crosstalk: therapeutic targets and perspectives |
publisher |
Elsevier |
publishDate |
2022 |
url |
http://irep.iium.edu.my/102044/1/IBRO_REPORT_1-s2.0-S2667242122000999-main.pdf http://irep.iium.edu.my/102044/7/102044_Neurodegeneration%20and%20inflammation%20crosstalk_SCOPUS.pdf http://irep.iium.edu.my/102044/8/102044_Neurodegeneration%20and%20inflammation%20crosstalk.pdf http://irep.iium.edu.my/102044/ https://www.sciencedirect.com/science/article/pii/S2667242122000999/pdfft?md5=b1870afb63f84e2876d68c70cf7df0c0&pid=1-s2.0-S2667242122000999-main.pdf https://doi.org/10.1016/j.ibneur.2022.12.003 |
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