Effect of crataegus aronia on the biochemical parameters in induced diabetic rats
Crataegus aronia is widely known for its antioxidant, anti-inflammatory, and hypolipidemic properties, and it has traditionally been used to treat cardiovascular disorders. This study aimed to evaluate the impact of Crataegus aronia extract on the liver enzyme markers, blood glucose levels, lipid...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
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2022
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| Online Access: | http://irep.iium.edu.my/103153/2/103153_Effect%20of%20crataegus%20aronia%20on%20the%20biochemical%20parameters.pdf http://irep.iium.edu.my/103153/3/103153_Effect%20of%20crataegus%20aronia%20on%20the%20biochemical%20parameters_Scopus.pdf http://irep.iium.edu.my/103153/ https://www.phcogj.com/about-journal |
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| Institution: | Universiti Islam Antarabangsa Malaysia |
| Language: | English English |
| Summary: | Crataegus aronia is widely known for its antioxidant, anti-inflammatory, and hypolipidemic properties, and
it has traditionally been used to treat cardiovascular disorders. This study aimed to evaluate the impact
of Crataegus aronia extract on the liver enzyme markers, blood glucose levels, lipid profiles, and kidney
function biomarkers as well as hematological parameters in induced diabetic rats. Male Wistar rats were
divided into seven groups: normal Control; Diabetic; and Diabetic animals treated with two doses of
Crataegus aronia extract (5 and 10mg/kg) (DM+extract), Control treated with the extract ( 5 and 10mg/
kg) and induced diabetic treated with insulin. Streptozotocin (STZ)-induced diabetic rats (50mg/kg, ip)and
normal were orally administrated with Crataegus aronia extract once a day for 4 weeks. At the end of
the experiment, the biochemical and hematological parameters were measured in all groups. Also, the
phytochemicals and antioxidant activity of the Crataegus aronia extract were evaluated. According to
findings, the total phenols, total flavonoid, and flavonol contents were 538.3 mg Galic acid equivalent /g
extract, 149.3 mg Rutin equivalent / g extract, and 79.3 mg Rutin equivalent / g extract), respectively. The
antioxidant activity according to 2,2-diphenyl-2-picrylhydrazyl (DPPH) IC50 and ferric reducing antioxidant
power (FRAP) assays were 28.02 µg/ml and in the range of 0.273 – 0.960 µmol Fe+2/g dw, respectively.
Crataegus aronia extract significantly (p <0.05) affects red blood cells, hemoglobin, hematocrit, white
blood cells, lymphocytes, and platelets values. Also, Crataegus aronia had a significant (P < 0.05) effect
on serum biochemical parameters, including glucose, total proteins, albumins, triglycerides, creatinine,
bilirubin, and serum aspartate aminotransferase (AST). However, Crataegus aronia treatment had no
significant effects (p < 0.05) on serum alanine aminotransferase, alkaline phosphatase, and cholesterol
levels. Crataegus aronia exerts antioxidant activity and significantly improves the biochemical and
hematological biomarkers in induced diabetic rats. |
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