The NLRP3 inflammasome in age-related cerebral small vessel disease manifestations: untying the innate immune response connection

• Main Authors: Che Mohd Nassir, Che Mohd Nasril, Damodaran, Thenmoly, Ismail, Nurul Iman, Hashim, Sabarisah, Jaffer, Usman, Abdul Hamid, Hafizah, Mehat, Muhammad Zulfadli, Norazit, Anwar, Mustapha, Muzaimi
• Format: Article
• Language: English; English
• Published: Multidisciplinary Digital Publishing Institute (MDPI) 2023
• Subjects: RC321 Neuroscience. Biological psychiatry. Neuropsychiatry; RC633 Specialties of Internal Medicines- Diseases of The Blood and Blood-forming Organs. Hematologic Diseases; RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
• Online Access: http://irep.iium.edu.my/103207/8/103207_The%20NLRP3%20inflammasome%20in%20age-related%20cerebral_SCOPUS.pdf; http://irep.iium.edu.my/103207/9/103207_The%20NLRP3%20inflammasome%20in%20age-related%20cerebral.pdf; http://irep.iium.edu.my/103207/; https://www.mdpi.com/2075-1729/13/1/216
• Institution: Universiti Islam Antarabangsa Malaysia

In this narrative review, we present the evidence on nucleotide-binding and oligomerization (NOD) domain-like receptor (NLR) family pyrin domain (PYD)-containing 3 (NLRP3) inflammasome activation for its putative roles in the elusive pathomechanism of aging-related cerebral small vessel disease (CSV...