Insight parameter drug design for human β-tryptase inhibition integrated molecular docking, QSAR, molecular dynamics simulation, and pharmacophore modelling studies of α-keto-[1,2,4]-oxadiazoles

• Main Authors: Yu, Chai Xin, Tan, Jian Wei, Rullah, Kamal, Imran, Syahrul, Tham, Chau Ling
• Format: Article
• Language: English; English; English
• Published: Taylor and Francis 2023
• Subjects: RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/104156/4/104156_Insight%20parameter%20drug%20design%20for%20human%20%CE%B2-tryptase_WOS.pdf; http://irep.iium.edu.my/104156/5/104156_Insight%20parameter%20drug%20design%20for%20human%20%CE%B2-tryptase_SCOPUS.pdf; http://irep.iium.edu.my/104156/6/104156_Insight%20parameter%20drug%20design%20for%20human%20%CE%B2-tryptase.pdf; http://irep.iium.edu.my/104156/; https://www.tandfonline.com/doi/abs/10.1080/07391102.2023.2171131?journalCode=tbsd20; https://doi.org/10.1080/07391102.2023.2171131
• Institution: Universiti Islam Antarabangsa Malaysia

Dengue hemorrhagic fever (DHF) is severe dengue with a hallmark of vascular leakage. b-tryptase has been found to promote vascular leakage in DHF patients, which could be a potential target for DHF treatment. This study aims to develop a theoretical background for designing and selecting human b-try...