Proteomic perspective of metabolic dysregulation in schizophrenia: a brief review

• Main Authors: Mat Rasid, Siti Norain, Abd. Rahim, Nour El Huda, Azman, Norainin Sofiya, A.Talib, Norlelawati, Abdull Jalil, Mohd Asyraf, Md Rosli, Ahmad Nabil
• Format: Proceeding Paper
• Language: English; English; English
• Published: 2023
• Subjects: Q Science (General); R Medicine (General); RA790 Mental Health. Mental Illness Prevention
• Online Access: http://irep.iium.edu.my/107572/1/Abstract%20PG%20Colloquium_G2217818.pdf; http://irep.iium.edu.my/107572/2/PG%20Colloquium%20booklet.pdf; http://irep.iium.edu.my/107572/18/107572_Proteomic%20perspective%20of%20metabolic%20dysregulation.pdf; http://irep.iium.edu.my/107572/; https://centre.iium.edu.my/cps/2023/07/21/postgraduate-colloquium-2023/
• Institution: Universiti Islam Antarabangsa Malaysia

The genetic makeup of schizophrenia is intricate and diverse, and its underlying pathophysiology remains elusive. Fortunately, there is evidence linking the dysregulation of metabolic balance to schizophrenia. Therefore, this review provides a summary of proteomic investigations in schizophrenia, specifically focusing on their relation to metabolic dysregulation. Articles were retrieved following an advanced search in SCOPUS, PubMed and Google Scholar limited to the English language published papers between 2000-2023. The search strategy was performed using the following keywords: “proteomic”, “schizophrenia”, “metabolic” and “obesity”. Following a thorough examination of the content of each article, a total of fifteen relevant articles were identified and included in this review. As a whole, the papers manifested that the predominant methodology employed in schizophrenia research to investigate metabolic imbalance through a proteomic approach primarily involves the utilization of blood and tissue samples. The analysis of protein expression in individuals with schizophrenia reveals that biochemical processes contribute as mechanisms that heighten the vulnerability to metabolic dysregulation, regardless of whether they are receiving antipsychotic medication or not. This review proposes that proteomic approaches have emerged as valuable tools to unravel the pathogenesis of this disorder and identify the potential biomarkers in schizophrenia. Moreover, the outcomes of these studies have the potential for future research that could aid psychiatrists in choosing treatment approaches customized for schizophrenia patients who are also dealing with obesity. This is due to the evidence presented in this review indicating a substantial link between antipsychotic medication, particularly second-generation antipsychotics, and their involvement in metabolic disturbances that contribute to the development of obesity