Benzimidazole derivatives as potential neuraminidase inhibitors: conventional and microwave synthesis, in vitro and molecular docking analysis

• Main Authors: Hamzah, Nurasyikin, Abd Hamid, Shafida, Abdul Rahim, Aisyah Saad, Abdul Wahab, Habibah
• Format: Article
• Language: English; English
• Published: Malaysian Analytical Sciences Society (ANALIS) 2023
• Subjects: QD Chemistry; RM300 Drugs and their action
• Online Access: http://irep.iium.edu.my/107762/7/107762_Benzimidazole%20derivatives%20as%20potential%20neuraminidase%20inhibitors.pdf; http://irep.iium.edu.my/107762/13/107762_Benzimidazole%20derivatives%20as%20potential%20neuraminidase%20inhibitors%20conventional%20and%20microwave%20synthesis_Scopus.pdf; http://irep.iium.edu.my/107762/; https://mjas.analis.com.my/mjas/v27_n5/pdf/Hamzah_27_5_8.pdf
• Institution: Universiti Islam Antarabangsa Malaysia

As a continuous effort to discover potential neuraminidase (NA) inhibitors, two series of benzimidazole derivatives consisting of esters, 5(a–g) and carboxylic acid moieties, 6(a–g) were synthesised under conventional and microwave conditions. The efficiency of both methods was compared, and their...