C-reactive protein, albumin, urea, crp/albumin ratio, and urea/albumin ratio: a retrospective evaluation in Covid-19 patients
Introduction: C-reactive protein (CRP), urea, albumin, CRP/albumin ratio (CAR) and urea/albumin ratio (UAR) could be valuable biomarkers for determining the severity of illness in patients with COVID-19. This study aimed to determine the association between these markers and disease severity in COVI...
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Faculty of Medicine and Health Sciences, University Putra Malaysia
2023
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my.iium.irep.1081402024-01-08T06:09:05Z http://irep.iium.edu.my/108140/ C-reactive protein, albumin, urea, crp/albumin ratio, and urea/albumin ratio: a retrospective evaluation in Covid-19 patients Mohammad Nazri, Nor Amirah Wan Azman, Wan Norlina Musa, Norsyuhadah Tuan Ismail, Tuan Salwani Harun, Azian Yaacob, Najib Majdi Sulong, Sarina Kuttulebbai Naina Mohamed Salam, Sirajudeen Che Mat, Mahaya Zulkeflee, Hani Ajrina Mustapa, Siti Sarah R Medicine (General) Introduction: C-reactive protein (CRP), urea, albumin, CRP/albumin ratio (CAR) and urea/albumin ratio (UAR) could be valuable biomarkers for determining the severity of illness in patients with COVID-19. This study aimed to determine the association between these markers and disease severity in COVID-19 patients on admission and days five to seven after admission. Methods: This retrospective study includes 153 adult COVID-19 patients admitted to Hospital Raja Perempuan Zainab II and Hospital Ampang from January 2021 to December 2021. Patients’ serum CRP, urea, albumin and creatinine levels were recorded on admission and on days five to seven after admission. The patients were categorised based on the Annex 2e guidelines published by the Ministry of Health, Malaysia and further classified as mild to moderate disease (stages 1-3) and severe to critical illness (stages 4-5). Results: On admission, urea, creatinine, CRP, UAR and CAR were significantly higher in the severe to critical group (p<0.001). The optimal cut-off value for the UAR was 0.16; the area under the curve (AUC) was 0.760, and sensitivity and specificity were 63.6% and 85.7%, respectively. The AUC of the CAR was 0.752, with 54.2% sensitivity and 91.4% specificity at an optimal cut-off value of 1.63. In severe to critical COVID-19 patients, albumin levels decreased significantly on days five to seven after admission, while urea levels remained significantly higher in this group (p<0.001, p<0.05, respectively). Conclusion: CRP, urea, albumin, CAR and UAR are promising biomarkers for predicting the severity of disease in COVID-19 patients. Faculty of Medicine and Health Sciences, University Putra Malaysia 2023-11-15 Article PeerReviewed application/pdf en http://irep.iium.edu.my/108140/7/108140_C-reactive%20protein%2C%20albumin%2C%20urea%2C%20crp.pdf application/pdf en http://irep.iium.edu.my/108140/13/108140_%20C-reactive%20protein%2C%20albumin%2C%20urea_Scopus.pdf Mohammad Nazri, Nor Amirah and Wan Azman, Wan Norlina and Musa, Norsyuhadah and Tuan Ismail, Tuan Salwani and Harun, Azian and Yaacob, Najib Majdi and Sulong, Sarina and Kuttulebbai Naina Mohamed Salam, Sirajudeen and Che Mat, Mahaya and Zulkeflee, Hani Ajrina and Mustapa, Siti Sarah (2023) C-reactive protein, albumin, urea, crp/albumin ratio, and urea/albumin ratio: a retrospective evaluation in Covid-19 patients. Malaysian Journal of Medicine and Health Sciences, 19 (6). pp. 164-170. E-ISSN 2636-9346 https://medic.upm.edu.my/upload/dokumen/2023111410464421_MJMHS_1367.pdf doi:10.47836/mjmhs.19.6.22 |
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R Medicine (General) Mohammad Nazri, Nor Amirah Wan Azman, Wan Norlina Musa, Norsyuhadah Tuan Ismail, Tuan Salwani Harun, Azian Yaacob, Najib Majdi Sulong, Sarina Kuttulebbai Naina Mohamed Salam, Sirajudeen Che Mat, Mahaya Zulkeflee, Hani Ajrina Mustapa, Siti Sarah C-reactive protein, albumin, urea, crp/albumin ratio, and urea/albumin ratio: a retrospective evaluation in Covid-19 patients |
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Introduction: C-reactive protein (CRP), urea, albumin, CRP/albumin ratio (CAR) and urea/albumin ratio (UAR) could be valuable biomarkers for determining the severity of illness in patients with COVID-19. This study aimed to determine the association between these markers and disease severity in COVID-19 patients on admission and days five to seven after admission. Methods: This retrospective study includes 153 adult COVID-19 patients admitted to Hospital Raja Perempuan Zainab II and Hospital Ampang from January 2021 to December 2021. Patients’ serum CRP, urea, albumin and creatinine levels were recorded on admission and on days five to seven after admission. The patients were categorised based on the Annex 2e guidelines published by the Ministry of Health, Malaysia and further classified as mild to moderate disease (stages 1-3) and severe to critical illness (stages 4-5). Results: On admission, urea, creatinine, CRP, UAR and CAR were significantly higher in the severe to critical group (p<0.001). The optimal cut-off value for the UAR was 0.16; the area under the curve (AUC) was 0.760, and sensitivity and specificity were 63.6% and 85.7%, respectively. The AUC of the CAR was 0.752, with 54.2% sensitivity and 91.4% specificity at an optimal cut-off value of 1.63. In severe to critical COVID-19 patients, albumin levels decreased significantly on days five to seven after admission, while urea levels remained significantly higher in this group (p<0.001, p<0.05, respectively). Conclusion: CRP, urea, albumin, CAR and UAR are promising biomarkers for predicting the severity of disease in COVID-19 patients. |
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Article |
author |
Mohammad Nazri, Nor Amirah Wan Azman, Wan Norlina Musa, Norsyuhadah Tuan Ismail, Tuan Salwani Harun, Azian Yaacob, Najib Majdi Sulong, Sarina Kuttulebbai Naina Mohamed Salam, Sirajudeen Che Mat, Mahaya Zulkeflee, Hani Ajrina Mustapa, Siti Sarah |
author_facet |
Mohammad Nazri, Nor Amirah Wan Azman, Wan Norlina Musa, Norsyuhadah Tuan Ismail, Tuan Salwani Harun, Azian Yaacob, Najib Majdi Sulong, Sarina Kuttulebbai Naina Mohamed Salam, Sirajudeen Che Mat, Mahaya Zulkeflee, Hani Ajrina Mustapa, Siti Sarah |
author_sort |
Mohammad Nazri, Nor Amirah |
title |
C-reactive protein, albumin, urea, crp/albumin ratio, and urea/albumin ratio: a retrospective evaluation in Covid-19 patients |
title_short |
C-reactive protein, albumin, urea, crp/albumin ratio, and urea/albumin ratio: a retrospective evaluation in Covid-19 patients |
title_full |
C-reactive protein, albumin, urea, crp/albumin ratio, and urea/albumin ratio: a retrospective evaluation in Covid-19 patients |
title_fullStr |
C-reactive protein, albumin, urea, crp/albumin ratio, and urea/albumin ratio: a retrospective evaluation in Covid-19 patients |
title_full_unstemmed |
C-reactive protein, albumin, urea, crp/albumin ratio, and urea/albumin ratio: a retrospective evaluation in Covid-19 patients |
title_sort |
c-reactive protein, albumin, urea, crp/albumin ratio, and urea/albumin ratio: a retrospective evaluation in covid-19 patients |
publisher |
Faculty of Medicine and Health Sciences, University Putra Malaysia |
publishDate |
2023 |
url |
http://irep.iium.edu.my/108140/7/108140_C-reactive%20protein%2C%20albumin%2C%20urea%2C%20crp.pdf http://irep.iium.edu.my/108140/13/108140_%20C-reactive%20protein%2C%20albumin%2C%20urea_Scopus.pdf http://irep.iium.edu.my/108140/ https://medic.upm.edu.my/upload/dokumen/2023111410464421_MJMHS_1367.pdf |
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1787520328477442048 |