Chemical composition, antifungal, antibiofilm, and molecular docking studies of syzygium dyerianum essential oil

• Main Authors: Mohd Rahim, Faezatul Alwani, Wan Salleh, Wan Mohd Nuzul Hakimi, Arzmi, Mohd Hafiz, Salihu, Abubakar Siddiq
• Format: Article
• Language: English; English
• Published: Walter de Gruyter 2024
• Subjects: QK Botany; QR Microbiology
• Online Access: http://irep.iium.edu.my/111333/2/111333_Chemical%20composition%2C%20antifungal%2C%20antibiofilm%2C%20and%20molecular%20docking.pdf; http://irep.iium.edu.my/111333/8/111333_Chemical%20composition%2C%20antifungal%2C%20antibiofilm%2C%20and%20molecular%20docking_SCOPUS.pdf; http://irep.iium.edu.my/111333/; https://www.degruyter.com/document/doi/10.1515/znc-2023-0133/html
• Institution: Universiti Islam Antarabangsa Malaysia

The current study describes the chemical compo- sition, antifungal, antibiofilm, antibacterial and molecular docking studies of Syzygium dyerianum growing in Malaysia. The essential oil was obtained through hydrodistillation and characterized using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The antifungal and antibacterial activities were developed using the broth microdilution assay, whereas the effect on the microbial biofilms was determined using a semi-quantitative static bio- film assay. A total of 31 components were identified, which represent 99.5 % of the essential oil. The results revealed that the essential oil consisted mainly of β-pinene (15.6%), α-terpineol (13.3%), α-pinene (11.1%), caryophyllene oxide (8.8%), limonene (8.1%), borneol (6.0%) and viridiflorol (5.1 %). The results of the microdilution method showed that essential oil exhibited activity against Candida albicans and Streptococcus mutans with minimal inhibitory concentration values of 125 and 250μg/mL, respectively. Furthermore, essential oil decreased the biofilm of C. albicans and S. mutans by 20.11 ± 0.27% and 32.10 ± 4.81% when treated with 250μg/mL. The best docking energy was observed with viridiflorol (−29.7 kJ/mol). This study highlights that essential oil can potentially be a natural antifungal, antibacterial, and antibiofilm agent that could be applied in the pharmaceutical and food industries.