The role of treponema denticola in the periodontitis alveolar bone damage: a systematic review
ABSTRACT Background: Periodontitis is a chronic inflammation condition of the periodontal tissue, which causes irreversible, progressive deterioration of the tooth-supporting tissue, leading to tooth loss. One of the main bacteria in the pathogenesis of periodontitis is Treponema denticola. Its...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Dentistry, Universitas Islam Sultan Agung
2023
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/111372/2/111372_The%20role%20of%20treponema%20denticola.pdf http://irep.iium.edu.my/111372/ https://jurnal.unissula.ac.id/index.php/odj/article/view/33065/9365 http://dx.doi.org/10.30659/odj.10.2.314-325 |
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| Institution: | Universiti Islam Antarabangsa Malaysia |
| Language: | English |
| Summary: | ABSTRACT
Background: Periodontitis is a chronic inflammation condition of the
periodontal tissue, which causes irreversible, progressive deterioration of the
tooth-supporting tissue, leading to tooth loss. One of the main bacteria in the
pathogenesis of periodontitis is Treponema denticola. Its involvement in
periodontitis includes producing and releasing various virulence factors that
further modulate inflammation and ignite alveolar bone destruction.To examine
Treponema denticola's role in the mechanism of alveolar bone damage in
periodontitis.
Method: This systematic review was conducted from August 2021 until April
2022. Qualified literature is evaluated based on inclusion criteria, including
published in English within the last ten years and research articles available in
full text. The inclusion literature’s determination was based on the PRISMA
(Preferred Reporting Item for Systematic Review and Meta-Analysis).
Result: Six journals fit the inclusion criteria and discuss Treponema denticola
involvement in alveolar bone destruction via several mechanisms, including
periplasmic flagella as its virulence factor. Treponema denticola can inhibit
osteogenic cell differentiation and induce the production TNF-α, IL-6, and IL1β, which are the proinflammatory cytokines involved in osteoclastogenesis.
The induction mechanism of these various cytokines can ultimately increase
osteoclast differentiation by increasing RANKL expression and decreasing
OPG expression.
Conclusion: Treponema denticola is involved in alveolar bone destruction by
inhibiting bone formation and inducing an inflammatory response in immune
cells that can increase osteoclast differentiation, as observed in alveolar bone
destruction. |
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