Four recurrent miscarriages – Is it a case of antiphospholipid syndrome?

Introduction: Antiphospholipid syndrome (APLS) is usually clinically suspected in antenatal women presented with recurrent miscarriages. Screening is usually conducted, especially for those with persistent, unexplained recurrent miscarriages in the first trimester. However, most patients might not...

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Main Authors: Roop Kishore, Yashdev Atri, Shalihin, Mohd Shaiful Ehsan
Format: Article
Language:English
Published: 2024
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Online Access:http://irep.iium.edu.my/113054/2/113054_Four%20recurrent%20miscarriages%20%E2%80%93%20Is%20it%20a%20case%20of%20Antiphospholipid%20Syndrome.pdf
http://irep.iium.edu.my/113054/
https://journals.iium.edu.my/ijahs/index.php/IJAHS/article/view/806
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spelling my.iium.irep.1130542024-07-10T00:26:04Z http://irep.iium.edu.my/113054/ Four recurrent miscarriages – Is it a case of antiphospholipid syndrome? Roop Kishore, Yashdev Atri Shalihin, Mohd Shaiful Ehsan R Medicine (General) RA Public aspects of medicine RC Internal medicine RG Gynecology and obstetrics Introduction: Antiphospholipid syndrome (APLS) is usually clinically suspected in antenatal women presented with recurrent miscarriages. Screening is usually conducted, especially for those with persistent, unexplained recurrent miscarriages in the first trimester. However, most patients might not seek medical attention earlier, causing a delay in screening. Nevertheless, it is a dilemma for patients with recurrent miscarriages, especially up to four miscarriages, to be presumed as APLS until proven otherwise. Case: We reported a 37-year-old Gravida 5 Para 0+4 at four weeks of amenorrhoea presented with one episode of per vaginal bleeding. APLS and other relevant causative screenings had been performed, and the results were normal. Surprisingly, her pregnancy is still viable and progressing well. Discussion: This case proved that recurrent miscarriages on more than three occasions are not always equivalent to antiphospholipid syndrome. The underlying cause can be idiopathic or other causes that have not been investigated yet, including the possibility of a congenital anomaly. Conclusion: Suspicion of APLS is warranted and should be verified with the gold standard screening tests. In any case, where the results were normal, further assessments such as uterine evaluation, infectious disease screening, and pathological examination should be considered. Pre-pregnancy screening should be a minimal requirement for all women of reproductive age for the evaluation and prevention of similar outcomes to those of other women. 2024-07-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/113054/2/113054_Four%20recurrent%20miscarriages%20%E2%80%93%20Is%20it%20a%20case%20of%20Antiphospholipid%20Syndrome.pdf Roop Kishore, Yashdev Atri and Shalihin, Mohd Shaiful Ehsan (2024) Four recurrent miscarriages – Is it a case of antiphospholipid syndrome? International Journal of Allied Health Sciences, 8 (2). pp. 3005-3008. E-ISSN 2600-8491 https://journals.iium.edu.my/ijahs/index.php/IJAHS/article/view/806
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
RA Public aspects of medicine
RC Internal medicine
RG Gynecology and obstetrics
spellingShingle R Medicine (General)
RA Public aspects of medicine
RC Internal medicine
RG Gynecology and obstetrics
Roop Kishore, Yashdev Atri
Shalihin, Mohd Shaiful Ehsan
Four recurrent miscarriages – Is it a case of antiphospholipid syndrome?
description Introduction: Antiphospholipid syndrome (APLS) is usually clinically suspected in antenatal women presented with recurrent miscarriages. Screening is usually conducted, especially for those with persistent, unexplained recurrent miscarriages in the first trimester. However, most patients might not seek medical attention earlier, causing a delay in screening. Nevertheless, it is a dilemma for patients with recurrent miscarriages, especially up to four miscarriages, to be presumed as APLS until proven otherwise. Case: We reported a 37-year-old Gravida 5 Para 0+4 at four weeks of amenorrhoea presented with one episode of per vaginal bleeding. APLS and other relevant causative screenings had been performed, and the results were normal. Surprisingly, her pregnancy is still viable and progressing well. Discussion: This case proved that recurrent miscarriages on more than three occasions are not always equivalent to antiphospholipid syndrome. The underlying cause can be idiopathic or other causes that have not been investigated yet, including the possibility of a congenital anomaly. Conclusion: Suspicion of APLS is warranted and should be verified with the gold standard screening tests. In any case, where the results were normal, further assessments such as uterine evaluation, infectious disease screening, and pathological examination should be considered. Pre-pregnancy screening should be a minimal requirement for all women of reproductive age for the evaluation and prevention of similar outcomes to those of other women.
format Article
author Roop Kishore, Yashdev Atri
Shalihin, Mohd Shaiful Ehsan
author_facet Roop Kishore, Yashdev Atri
Shalihin, Mohd Shaiful Ehsan
author_sort Roop Kishore, Yashdev Atri
title Four recurrent miscarriages – Is it a case of antiphospholipid syndrome?
title_short Four recurrent miscarriages – Is it a case of antiphospholipid syndrome?
title_full Four recurrent miscarriages – Is it a case of antiphospholipid syndrome?
title_fullStr Four recurrent miscarriages – Is it a case of antiphospholipid syndrome?
title_full_unstemmed Four recurrent miscarriages – Is it a case of antiphospholipid syndrome?
title_sort four recurrent miscarriages – is it a case of antiphospholipid syndrome?
publishDate 2024
url http://irep.iium.edu.my/113054/2/113054_Four%20recurrent%20miscarriages%20%E2%80%93%20Is%20it%20a%20case%20of%20Antiphospholipid%20Syndrome.pdf
http://irep.iium.edu.my/113054/
https://journals.iium.edu.my/ijahs/index.php/IJAHS/article/view/806
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