Analysis of bone destruction mechanism by aggregatibacter actinomycetemcomitans: a systematic review
Periodontitis is a disease marked by inflammation of the periodontium, caused by biofilms present in the oral cavity, and results in alveolar bone destruction. One of the main hallmarks of periodontitis is the presence of Aggregatibacter actinomycetecomitans, which is generally suppressed by antib...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Dentistry, Universitas Indonesia
2024
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/114215/7/114215_Analysis%20of%20bone%20destruction%20mechanism.pdf http://irep.iium.edu.my/114215/ https://scholarhub.ui.ac.id/cgi/viewcontent.cgi?article=1700&context=jdi https://doi.org/10.14693/jdi.v31i2.1700 |
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| Institution: | Universiti Islam Antarabangsa Malaysia |
| Language: | English |
| Summary: | Periodontitis is a disease marked by inflammation of the periodontium, caused by biofilms present in the oral
cavity, and results in alveolar bone destruction. One of the main hallmarks of periodontitis is the presence of
Aggregatibacter actinomycetecomitans, which is generally suppressed by antibiotic administration. The strategy
to control A. actinomycetecomitans by small specific peptide inhibitors potentially halts the progression of
alveolar bone damage while lowering the risk of antibiotic resistance. The detailed interaction mechanisms of
A. actinomycetecomitans and bone cells are fundamental to discovering and constructing the specific inhibitor.
Objective: : To systematically review the mechanism of bone destruction by A. actinomycetecomitans based
on its interaction with bone cells and its precursors. Methods: A comprehensive search was performed in two
database (Scopus, PubMed) from September 2021 to June 2022, according to the Preferred Reporting Items for
SystematicvReviews and Meta-Analyses (PRISMA) protocol. The terms used in the search were ”Aggregatibacter
actinomycetemcomitans” OR “A. actinomycetemcomitans” AN” bone”OR “bone loss” OR “bone destruction” OR
“bone resorption” OR “bone formation” OR “bone remodelling” OR “osteclast” OR “osteoblast” OR “osteocyte”.
Only articles in English and research articles published within ten years were included. Results: In total, nine
articles discussing alveolar bone destruction were included in the review. Most articles reported the virulence of
A. actinomycetecomitans, lipopolysaccharide (LPS), and its target cells, osteoclast progenitors, osteoclasts, and
osteoblasts. Conclusion: A. actinomycetecomitans induces alveolar bone destruction via various mechanisms,
including osteoblast apoptosis, lowering osteoblast differentiation, increasing osteoclast activity and differentiation,
and releasing inflammatory cytokines. The detailed interaction mechanisms between A. actinomycetecomitans and
bone cells would provide valuable hints for further investigation toward constructing specific inhibitors to disrupt
the interaction between A. actinomycetecomitans and bone cells that eventually protect the alveolar bone destruction. |
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