Immunogenicity of monoclonal antibody: causes, consequences, and control strategies

• Main Authors: Asmani, Ahmad Zafran Amin, Zainuddin, Ahmad Faris Fahmi, Ahmad Azmi Murad, Nadhirah, Mohd Darwis, Nur Hidayati, Suhaimi, Nur Suhaida, Zaini, Erizal, Bakhtiar, M. Taher, Darnis, Deny Susanti, Khotib, Junaidi
• Format: Article
• Language: English
• Published: Elsevier 2024
• Subjects: RS192 Materia Medica-Pharmaceutical Technology
• Online Access: http://irep.iium.edu.my/114788/7/114788_%20Immunogenicity%20of%20monoclonal%20antibody.pdf; http://irep.iium.edu.my/114788/; https://www.sciencedirect.com/journal/pathology-research-and-practice; https://doi.org/10.1016/j.prp.2024.155627
• Institution: Universiti Islam Antarabangsa Malaysia

Antibody-based treatment was first used in 1891 for the treatment of diphtheria. Since then, monoclonal antibodies (mAbs) have been developed to treat many diseases such as cancer and act as vaccines. However, murine-derived therapeutic mAbs were found to be highly immunogenic, and caused anti-drug...