Molecular docking studies of phytochemicals from azadirachta indica with trehalose–6-phosphate phosphatase of pathogenic microbes

• Main Authors: Azmihan, Adam, Johari, Nurul Anis, Abdullah, Mohamad Zakkirun, Bakar, Latifah Munirah
• Format: Article
• Language: English; English
• Published: Malaysian Institute of Chemistry 2024
• Subjects: QH301 Biology; QR Microbiology; RS Pharmacy and materia medica; TP248.13 Biotechnology
• Online Access: http://irep.iium.edu.my/114902/7/114902_Molecular%20docking%20studies%20of%20phytochemicals.pdf; http://irep.iium.edu.my/114902/13/114902_Molecular%20docking%20studies%20of%20phytochemicals_SCOPUS.pdf; http://irep.iium.edu.my/114902/; https://ikm.org.my/publications/malaysian-journal-of-chemistry/view-pdf.php?idx=J0052-2ce970f; https://doi.org/10.55373/mjchem.v26i5.194
• Institution: Universiti Islam Antarabangsa Malaysia

Trehalose-6-phosphate phosphatase (TPPs) is a particular enzyme involved in the biosynthesis pathways of trehalose that are often connected to the virulence of pathogenic microbes. Therefore, TPPs are targeted for therapeutic purposes. The inhibition of its biosynthesis pathway can achieve this. Aza...