Defect in ser46 phosphorylation of p53 protein: a resistance mechanism against p53 gene transfer in oral squamos cell carcinoma cells

• Main Authors: Arief Ichwan, Solachuddin Jauhari, Ikeda, Masa-Aki
• Format: Article
• Language: English
• Published: Japanese Association for Oral Biology 2008
• Subjects: RK Dentistry
• Online Access: http://irep.iium.edu.my/1257/1/Defect_in_ser46_phosphorylation_of_p53_protein.pdf; http://irep.iium.edu.my/1257/; http://www.jstage.jst.go.jp/article/joralbiosci/50/2/50_98/_article
• Institution: Universiti Islam Antarabangsa Malaysia

Oral squamous cell carcinoma (SCC) shows frequent metastasis and recurrence, ultimately with a poor outcome. The long-term survival rates of patients with oral SCC have not significantly been improved. The p53 tumor suppressor gene is known to be one of the most commonly mutated genes in human cance...