Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient for p53Ser46 phosphorylation

• Main Authors: Teng, Ma, Yamada, Shumpei, Ichwan, Solachuddin J. A., Ohtani, Kiyoshi, Otsu, Megumi, Ikeda, Masa-Aki
• Format: Article
• Language: English
• Published: ELSEVIER 2012
• Subjects: RB Pathology
• Online Access: http://irep.iium.edu.my/13889/1/Inability_of_p53-reactivating_compounds_Nutlin-3_and_RITA.pdf; http://irep.iium.edu.my/13889/; http://www.sciencedirect.com/science/article/pii/S0006291X11022029; http://dx.doi.org/10.1016/j.bbrc.2011.11.161
• Institution: Universiti Islam Antarabangsa Malaysia

The p53 tumor suppressor protein plays key roles in protecting cells from tumorigenesis. Phosphorylation of p53 at Ser46 (p53Ser46) is considered to be a crucial modification regulating p53- mediated apoptosis. Because the activity of p53 is impaired in most human cancers, restoration of wild-type p...