Expansion of human articular chondrocytes and formation of tissue-engineered cartilage: A step towards exploring a potential use of matrix-induced cell therapy

• Main Authors: Sha'ban, Munirah, Osman Cassim, Samsudin, Saim, Aminuddin, Idrus, Ruszymah
• Format: Article
• Language: English
• Published: Elsevier 2010
• Subjects: R Medicine (General)
• Online Access: http://irep.iium.edu.my/16958/1/Expansion_of_human_articular_chondrocytes_and_formation_of_tissue-engineered.pdf; http://irep.iium.edu.my/16958/; http://www.sciencedirect.com/science/article/pii/S0040816610000509; http://dx.doi.org/10.1016/j.tice.2010.07.002
• Institution: Universiti Islam Antarabangsa Malaysia

Monolayer culture expansion remains as a fundamental step to acquire sufficient number of cells for 3D constructs formation. It has been well-documented that cell expansion is however accompanied by cellular dedifferentiation. In order to promote cell growth and circumvent cellular dedifferentiation...